ST3GAL4

Protein-coding gene in the species Homo sapiens

ST3GAL4

Identifiers

Aliases

ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ, ST3 beta-galactoside alpha-2,3-sialyltransferase 4, ST-4, gal-NAc6S, ST3GalA.2

External IDs

OMIM: 104240; MGI: 1316743; HomoloGene: 4572; GeneCards: ST3GAL4; OMA:ST3GAL4 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q24.2	Start	126,355,640 bp^[1]
Band	11q24.2	End	126,440,344 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A4	Start	34,957,872 bp^[2]
Band	9\|9 A4	End	35,030,564 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left adrenal cortex

right adrenal cortex

left ovary

right ovary

rectum

C1 segment

right auricle

tibial nerve

transverse colon

right testis

Top expressed in

Ileal epithelium

jejunum

gallbladder

crypt of lieberkuhn of small intestine

molar

granulocyte

parotid gland

submandibular gland

duodenum

liver

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity glycosyltransferase activity sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity monosialoganglioside sialyltransferase activity
Cellular component	integral component of membrane Golgi apparatus Golgi cisterna membrane extracellular region extracellular exosome membrane Golgi membrane
Biological process	cognition O-glycan processing keratan sulfate biosynthetic process oligosaccharide metabolic process protein N-linked glycosylation via asparagine protein glycosylation glycoprotein biosynthetic process glycolipid biosynthetic process oligosaccharide biosynthetic process lipid glycosylation sialylation protein sialylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6484


20443

Ensembl


ENSG00000110080


ENSMUSG00000032038

UniProt


Q11206


Q91Y74

RefSeq (mRNA)

NM_001254757 NM_001254758 NM_001254759 NM_006278 NM_001348396
NM_001348398 NM_001348399 NM_001348400 NM_001348397


NM_009178

RefSeq (protein)

NP_001241686 NP_001241687 NP_001241688 NP_006269 NP_001335325
NP_001335327 NP_001335328 NP_001335329 NP_001335326


NP_033204

Location (UCSC)

Chr 11: 126.36 – 126.44 Mb

Chr 9: 34.96 – 35.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110080 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa H, Mattei MG, Paulson JC (Feb 1996). "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase". J Biol Chem. 271 (2): 931–8. doi:10.1074/jbc.271.2.931. PMID 8557707.
^ Kitagawa H, Paulson JC (Feb 1994). "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups". J Biol Chem. 269 (2): 1394–401. doi:10.1016/S0021-9258(17)42271-X. PMID 8288606.
^ "Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4".

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Chang ML, Eddy RL, Shows TB, Lau JT (1995). "Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies". Glycobiology. 5 (3): 319–25. doi:10.1093/glycob/5.3.319. PMID 7655169.
Sasaki K, Watanabe E, Kawashima K, et al. (1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J. Biol. Chem. 268 (30): 22782–7. doi:10.1016/S0021-9258(18)41595-5. PMID 7901202.
Basu SS, Basu M, Li Z, Basu S (1996). "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line". Biochemistry. 35 (16): 5166–74. doi:10.1021/bi960239l. PMID 8611500.
Saito S, Yamashita S, Endoh M, et al. (2003). "Clinical significance of ST3Gal IV expression in human renal cell carcinoma". Oncol. Rep. 9 (6): 1251–5. doi:10.3892/or.9.6.1251. PMID 12375029.
Grahn A, Larson G (2003). "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues". Glycoconj. J. 18 (10): 759–67. doi:10.1023/A:1021199300718. PMID 12441665. S2CID 11260655.
Moody AM, North SJ, Reinhold B, et al. (2003). "Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction". J. Biol. Chem. 278 (9): 7240–6. doi:10.1074/jbc.M210468200. PMID 12459555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Taniguchi A, Hioki M, Matsumoto K (2003). "Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines". Biochem. Biophys. Res. Commun. 301 (3): 764–8. doi:10.1016/S0006-291X(03)00041-X. PMID 12565846.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948. S2CID 9731951.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.