SRPRB

Protein-coding gene in the species Homo sapiens

SRPRB

Identifiers

Aliases

SRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta

External IDs

OMIM: 616883; MGI: 102964; HomoloGene: 6332; GeneCards: SRPRB; OMA:SRPRB - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q22.1	Start	133,784,023 bp^[1]
Band	3q22.1	End	133,825,772 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F1	Start	103,065,231 bp^[2]
Band	9\|9 F1	End	103,079,336 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of pancreas

parotid gland

islet of Langerhans

cartilage tissue

tibia

epithelium of nasopharynx

stromal cell of endometrium

periodontal fiber

pericardium

corpus epididymis

Top expressed in

saccule

otic placode

yolk sac

spermatocyte

renal corpuscle

neural layer of retina

otic vesicle

external carotid artery

parotid gland

internal carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding signal recognition particle binding GTP binding
Cellular component	endoplasmic reticulum membrane cytoplasmic microtubule cytoplasm integral component of membrane signal recognition particle receptor complex intracellular anatomical structure endoplasmic reticulum membrane
Biological process	IRE1-mediated unfolded protein response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


58477


20818

Ensembl


ENSG00000144867


ENSMUSG00000032553

UniProt


Q9Y5M8


P47758

RefSeq (mRNA)


NM_021203 NM_001379313


NM_009275

RefSeq (protein)


NP_067026 NP_001366242


NP_033301

Location (UCSC)

Chr 3: 133.78 – 133.83 Mb

Chr 9: 103.07 – 103.08 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.^[5]^[6]^[7]

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
^ Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
^ ^a ^b "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi:10.3748/wjg.v9.i8.1719. PMC 4611530. PMID 12918107.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297. S2CID 1871553.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

2fh5: The Structure of the Mammalian SRP Receptor
2go5: Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex