SIPA1L1

Protein-coding gene in the species Homo sapiens
SIPA1L1
Identifiers
AliasesSIPA1L1, E6TP1, signal induced proliferation associated 1 like 1, SPAR1
External IDsOMIM: 617504; MGI: 2443679; HomoloGene: 9189; GeneCards: SIPA1L1; OMA:SIPA1L1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIPA1L1
Genomic location for SIPA1L1
Band14q24.2Start71,320,449 bp[1]
End71,741,229 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for SIPA1L1
Genomic location for SIPA1L1
Band12|12 D1Start82,216,094 bp[2]
End82,498,560 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nucleus accumbens

  • testicle

  • external globus pallidus

  • caudate nucleus

  • Region I of hippocampus proper

  • right frontal lobe

  • right hemisphere of cerebellum

  • sural nerve

  • popliteal artery

  • tibial arteries
Top expressed in
  • olfactory tubercle

  • temporal lobe

  • nucleus accumbens

  • primary motor cortex

  • prefrontal cortex

  • amygdala

  • lateral septal nucleus

  • Region I of hippocampus proper

  • piriform cortex

  • vestibular membrane of cochlear duct
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • GTPase activator activity
  • ephrin receptor binding
  • molecular function
Cellular component
  • cytoplasm
  • postsynaptic membrane
  • membrane
  • postsynaptic density
  • plasma membrane
  • dendritic spine
  • synapse
  • cell junction
  • neuron projection
  • cytoskeleton
  • cellular component
Biological process
  • actin cytoskeleton reorganization
  • activation of GTPase activity
  • regulation of GTPase activity
  • ephrin receptor signaling pathway
  • regulation of synaptic plasticity
  • regulation of dendrite morphogenesis
  • regulation of axonogenesis
  • regulation of small GTPase mediated signal transduction
  • regulation of dendritic spine morphogenesis
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26037

217692

Ensembl

ENSG00000197555

ENSMUSG00000042700

UniProt

O43166

Q8C0T5

RefSeq (mRNA)
NM_001284245
NM_001284246
NM_001284247
NM_015556
NM_001354285

NM_001354286
NM_001354287
NM_001354288
NM_001354289
NM_001386936

NM_001167983
NM_172579

RefSeq (protein)
NP_001271174
NP_001271175
NP_001271176
NP_056371
NP_001341214

NP_001341215
NP_001341216
NP_001341217
NP_001341218

NP_001161455
NP_766167
NP_001394331
NP_001394332
NP_001394333

NP_001394334
NP_001394335
NP_001394336
NP_001394337
NP_001394338
NP_001394339
NP_001394340
NP_001394341
NP_001394342
NP_001394343
NP_001394344

Location (UCSC)Chr 14: 71.32 – 71.74 MbChr 12: 82.22 – 82.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197555 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042700 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (January 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Molecular and Cellular Biology. 19 (1): 733–44. doi:10.1128/mcb.19.1.733. PMC 83930. PMID 9858596.
  6. ^ "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Lee C, Wooldridge TR, Laimins LA (February 2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology. 358 (1): 201–10. doi:10.1016/j.virol.2006.08.028. PMID 16999984.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (December 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (August 2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron. 31 (2): 289–303. doi:10.1016/S0896-6273(01)00355-5. PMID 11502259.
  • Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
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