Protein-coding gene in the species Homo sapiens
SIDT1 |
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Identifiers |
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Aliases | SIDT1, B830021E24Rik, SID-1, SID1, SID1 transmembrane family member 1 |
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External IDs | OMIM: 606816; MGI: 2443155; HomoloGene: 41189; GeneCards: SIDT1; OMA:SIDT1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3q13.2 | Start | 113,532,555 bp[1] |
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End | 113,629,575 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16|16 B4 | Start | 44,060,543 bp[2] |
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End | 44,153,559 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right hemisphere of cerebellum
- rectum
- mucosa of sigmoid colon
- granulocyte
- right frontal lobe
- tonsil
- lymph node
- spleen
- gallbladder
- dorsolateral prefrontal cortex
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| Top expressed in | - primary visual cortex
- superior frontal gyrus
- lacrimal gland
- dentate gyrus of hippocampal formation granule cell
- primary motor cortex
- parotid gland
- zygote
- cerebellar cortex
- submandibular gland
- hippocampus proper
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - RNA transmembrane transporter activity
- RNA binding
- double-stranded RNA binding
| Cellular component | - membrane
- integral component of membrane
- lysosome
- plasma membrane
| Biological process | - dsRNA transport
- RNA transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001308350 NM_017699 NM_001322294 NM_001322295 NM_001322296
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NM_001322297 NM_001322298 NM_001322299 NM_001322300 |
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RefSeq (protein) | NP_001295279 NP_001309223 NP_001309224 NP_001309225 NP_001309226
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NP_001309227 NP_001309228 NP_001309229 NP_060169 |
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Location (UCSC) | Chr 3: 113.53 – 113.63 Mb | Chr 16: 44.06 – 44.15 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene. [5]
Function
The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000072858 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022696 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Elhassan MO, Christie J, Duxbury MS (2012). "Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance". J. Biol. Chem. 287 (8): 5267–77. doi:10.1074/jbc.M111.318865. PMC 3285307. PMID 22174421.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.