SFRS12

Protein-coding gene in the species Homo sapiens
SREK1
Identifiers
AliasesSREK1, SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDsOMIM: 609268; MGI: 2145245; HomoloGene: 10581; GeneCards: SREK1; OMA:SREK1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SREK1
Genomic location for SREK1
Band5q12.3Start66,139,971 bp[1]
End66,183,615 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for SREK1
Genomic location for SREK1
Band13|13 D1Start103,875,856 bp[2]
End103,911,116 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Achilles tendon

  • right uterine tube

  • corpus epididymis

  • ventricular zone

  • caput epididymis

  • body of pancreas

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • body of uterus
Top expressed in
  • genital tubercle

  • tail of embryo

  • Rostral migratory stream

  • neural layer of retina

  • yolk sac

  • zygote

  • pineal gland

  • medullary collecting duct

  • ventricular zone

  • lens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • nuclear speck
Biological process
  • mRNA processing
  • RNA splicing
  • regulation of alternative mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

140890

218543

Ensembl

ENSG00000153914

ENSMUSG00000032621

UniProt

Q8WXA9

Q8BZX4

RefSeq (mRNA)
NM_001077199
NM_001270492
NM_001270493
NM_139168
NM_001323527

NM_001323529
NM_001323533
NM_001323534
NM_001323535

NM_172592
NM_001361085

RefSeq (protein)
NP_001070667
NP_001257421
NP_001310456
NP_001310458
NP_001310462

NP_001310463
NP_001310464
NP_631907

NP_766180
NP_001348014

Location (UCSC)Chr 5: 66.14 – 66.18 MbChr 13: 103.88 – 103.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.[5][6]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153914 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032621 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.
  6. ^ a b "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940. S2CID 21158144.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
  • Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor". J. Biol. Chem. 277 (42): 39485–92. doi:10.1074/jbc.M201784200. PMID 12183448.
  • Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
  • Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
  • Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.


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