SF3B5

Protein-coding gene in the species Homo sapiens
SF3B5
Identifiers
AliasesSF3B5, SF3b10, Ysf3, splicing factor 3b subunit 5
External IDsOMIM: 617847; MGI: 1913375; HomoloGene: 41825; GeneCards: SF3B5; OMA:SF3B5 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SF3B5
Genomic location for SF3B5
Band6q24.2Start144,094,884 bp[1]
End144,095,573 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SF3B5
Genomic location for SF3B5
Band10|10 A2Start12,881,087 bp[2]
End12,884,927 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • mucosa of transverse colon

  • granulocyte

  • right adrenal gland

  • left adrenal cortex

  • right adrenal cortex

  • olfactory zone of nasal mucosa

  • body of pancreas

  • skin of leg

  • skin of abdomen
Top expressed in
  • internal carotid artery

  • endocardial cushion

  • efferent ductule

  • abdominal wall

  • mandibular prominence

  • external carotid artery

  • maxillary prominence

  • renal corpuscle

  • endothelial cell of lymphatic vessel

  • migratory enteric neural crest cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA binding
Cellular component
  • U12-type spliceosomal complex
  • spliceosomal complex
  • precatalytic spliceosome
  • nucleus
  • U2 snRNP
  • nucleoplasm
  • U2-type precatalytic spliceosome
Biological process
  • mRNA processing
  • RNA splicing
  • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83443

66125

Ensembl

ENSG00000169976

ENSMUSG00000078348

UniProt

Q9BWJ5

Q923D4

RefSeq (mRNA)

NM_031287

NM_175102

RefSeq (protein)

NP_112577

NP_780311

Location (UCSC)Chr 6: 144.09 – 144.1 MbChr 10: 12.88 – 12.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169976 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078348 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Luhrmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.
  6. ^ "Entrez Gene: SF3B5 splicing factor 3b, subunit 5, 10kDa".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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