ROBO2

Protein-coding gene in the species Homo sapiens

ROBO2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1UEM, 1UJT, 2EDJ

Identifiers

Aliases

ROBO2, SAX3, roundabout guidance receptor 2

External IDs

OMIM: 602431; MGI: 1890110; HomoloGene: 43188; GeneCards: ROBO2; OMA:ROBO2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p12.3	Start	75,906,695 bp^[1]
Band	3p12.3	End	77,649,964 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C3.1	Start	73,688,727 bp^[2]
Band	16\|16 C3.1	End	74,208,713 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

buccal mucosa cell

prefrontal cortex

islet of Langerhans

cartilage tissue

Brodmann area 46

pons

endothelial cell

gonad

Top expressed in

Rostral migratory stream

hand

genital tubercle

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

neural layer of retina

ganglionic eminence

primary visual cortex

olfactory bulb

superior colliculus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding axon guidance receptor activity
Cellular component	integral component of membrane membrane cell surface axolemma extracellular exosome plasma membrane
Biological process	cell differentiation ureteric bud development kidney development negative regulation of synapse assembly Roundabout signaling pathway positive regulation of axonogenesis nervous system development multicellular organism development chemotaxis central nervous system development cellular response to hormone stimulus olfactory bulb interneuron development apoptotic process involved in luteolysis negative regulation of negative chemotaxis axon midline choice point recognition metanephros development homophilic cell adhesion via plasma membrane adhesion molecules retinal ganglion cell axon guidance brain development spinal cord development axon guidance outflow tract septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion formation positive regulation of Notch signaling pathway involved in heart induction aorta development ventricular septum morphogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6092


268902

Ensembl


ENSG00000185008


ENSMUSG00000052516

UniProt


Q9HCK4


Q7TPD3

RefSeq (mRNA)

NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942
NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203 NM_001394212 NM_001394213 NM_001394214 NM_001395656 NM_001395657

NM_175549 NM_001358490 NM_001358491 NM_001358492 NM_001358493
NM_001358494

RefSeq (protein)

NP_001122401 NP_001276968 NP_001276969 NP_001276994 NP_002933
NP_001365119 NP_001365120 NP_001365121 NP_001365122 NP_001365123 NP_001365124 NP_001365125 NP_001365126 NP_001365127 NP_001365128 NP_001365129 NP_001365130 NP_001365131 NP_001365132


n/a

Location (UCSC)

Chr 3: 75.91 – 77.65 Mb

Chr 16: 73.69 – 74.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185008 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052516 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (January 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–215. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045. S2CID 2036419.
^ "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Hauptman G, Reichert MC, Abdal Rhida MA, Evans TA (December 2022). "Characterization of enhancer fragments in Drosophila robo2". Fly. 16 (1): 312–346. doi:10.1080/19336934.2022.2126259. PMC 9559326. PMID 36217698.
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, et al. (March 1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268. S2CID 16301178.
Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, et al. (March 1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–473. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527. S2CID 18663762.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, et al. (June 2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". The Journal of Neuroscience. 21 (12): 4281–4289. doi:10.1523/JNEUROSCI.21-12-04281.2001. PMC 6762758. PMID 11404413.
Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A (January 2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". The Journal of Comparative Neurology. 442 (2): 130–155. doi:10.1002/cne.10068. PMID 11754167. S2CID 24164570.
Hivert B, Liu Z, Chuang CY, Doherty P, Sundaresan V (December 2002). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Molecular and Cellular Neurosciences. 21 (4): 534–545. doi:10.1006/mcne.2002.1193. PMID 12504588. S2CID 19664833.
Grieshammer U, Plump AS, Wang F, Tessier-Lavigne M, Martin GR (May 2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site". Developmental Cell. 6 (5): 709–717. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
Yue Y, Grossmann B, Galetzka D, Zechner U, Haaf T (December 2006). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice". Genomics. 88 (6): 772–778. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, et al. (April 2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux". American Journal of Human Genetics. 80 (4): 616–632. doi:10.1086/512735. PMC 1852714. PMID 17357069.

PDB gallery

1uem: Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein
1ujt: Solution structure of the second fibronectin Type III domain of human KIAA1568 protein