RCAN2

Protein-coding gene in the species Homo sapiens
RCAN2
Identifiers
AliasesRCAN2, CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, regulator of calcineurin 2
External IDsOMIM: 604876; MGI: 1858219; HomoloGene: 130985; GeneCards: RCAN2; OMA:RCAN2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RCAN2
Genomic location for RCAN2
Band6p12.3Start46,220,736 bp[1]
End46,491,972 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RCAN2
Genomic location for RCAN2
Band17 B3|17 19.77 cMStart44,112,242 bp[2]
End44,350,407 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • Pars compacta

  • pars reticulata

  • pons

  • right ventricle

  • middle temporal gyrus

  • endothelial cell

  • external globus pallidus

  • Brodmann area 23

  • superior vestibular nucleus
Top expressed in
  • interventricular septum

  • extraocular muscle

  • motor neuron

  • superior colliculus

  • right ventricle

  • myocardium of ventricle

  • cardiac muscles

  • molar

  • central gray substance of midbrain

  • medial vestibular nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium-dependent protein serine/threonine phosphatase regulator activity
  • nucleic acid binding
Cellular component
  • cytoplasm
  • cellular component
Biological process
  • regulation of calcineurin-NFAT signaling cascade
  • calcium-mediated signaling
  • regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10231

53901

Ensembl

ENSG00000172348

ENSMUSG00000039601

UniProt

Q14206

Q9JHG2

RefSeq (mRNA)

NM_001251973
NM_001251974
NM_005822

NM_001286653
NM_001286654
NM_030598
NM_207649
NM_001357742

RefSeq (protein)

NP_001238902
NP_001238903
NP_005813

NP_001273582
NP_001273583
NP_085101
NP_997532
NP_001344671

Location (UCSC)Chr 6: 46.22 – 46.49 MbChr 17: 44.11 – 44.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RCAN2 is a gene that in humans encodes for the protein Calcipressin-2.

Calcipressin-2 is a protein that in humans is encoded by the RCAN2 gene.[5][6]

Summary box

N/A

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172348 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039601 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K, Yamamura H, Seo H (Aug 1996). "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts". J Biol Chem. 271 (24): 14567–71. doi:10.1074/jbc.271.24.14567. PMID 8662924.
  6. ^ "Entrez Gene: DSCR1L1 Down syndrome critical region gene 1-like 1".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Rothermel B, Vega RB, Yang J, et al. (2000). "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling". J. Biol. Chem. 275 (12): 8719–25. doi:10.1074/jbc.275.12.8719. PMID 10722714.
  • Strippoli P, Lenzi L, Petrini M, et al. (2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.
  • Fuentes JJ, Genescà L, Kingsbury TJ, et al. (2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Hum. Mol. Genet. 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295.
  • Cao X, Kambe F, Miyazaki T, et al. (2002). "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors". Biochem. J. 367 (Pt 2): 459–66. doi:10.1042/BJ20011797. PMC 1222895. PMID 12102656.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Qin L, Zhao D, Liu X, et al. (2007). "Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway". Mol. Cancer Res. 4 (11): 811–20. doi:10.1158/1541-7786.MCR-06-0126. PMID 17114339.
  • Gollogly LK, Ryeom SW, Yoon SS (2007). "Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis". J. Surg. Res. 142 (1): 129–36. doi:10.1016/j.jss.2006.10.011. PMC 1995402. PMID 17610901.


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