Protein-coding gene in the species Homo sapiens
RBMS1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | RBMS1, C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1, RNA binding motif single stranded interacting protein 1 |
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External IDs | OMIM: 602310; MGI: 1861774; HomoloGene: 9640; GeneCards: RBMS1; OMA:RBMS1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q24.2 | Start | 160,272,151 bp[1] |
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End | 160,493,807 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 C1.2 | Start | 60,580,537 bp[2] |
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End | 60,793,536 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tail of epididymis
- myocardium of left ventricle
- decidua
- cardiac muscle tissue of right atrium
- pericardium
- buccal mucosa cell
- tendon of biceps brachii
- skin of arm
- metanephric glomerulus
- skin of hip
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| Top expressed in | - stroma of bone marrow
- gastrula
- ciliary body
- left lung lobe
- decidua
- iris
- skin of external ear
- conjunctival fornix
- endothelial cell of lymphatic vessel
- genital tubercle
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - single-stranded DNA binding
- DNA binding
- double-stranded DNA binding
- protein binding
- nucleic acid binding
- RNA binding
- mRNA 3'-UTR binding
- poly(A) binding
- poly(U) RNA binding
| Cellular component | - nucleus
- cytoplasm
- cytosol
- ribonucleoprotein complex
| Biological process | - DNA replication
- RNA processing
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_002897 NM_016836 NM_016839 |
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NM_001141931 NM_001141932 NM_020296 |
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RefSeq (protein) | | |
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NP_001135403 NP_001135404 NP_064692 |
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Location (UCSC) | Chr 2: 160.27 – 160.49 Mb | Chr 2: 60.58 – 60.79 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.[5][6][7][8]
Function
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Multiple transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for this locus is found on chromosome 12.[8]
Interactions
RBMS1 has been shown to interact with Polymerase (DNA directed), alpha 1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000153250 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026970 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kanaoka Y, Nojima H (August 1994). "SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins". Nucleic Acids Res. 22 (13): 2687–93. doi:10.1093/nar/22.13.2687. PMC 308228. PMID 8041632.
- ^ Negishi Y, Nishita Y, Saëgusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SM, Ariga H (April 1994). "Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene". Oncogene. 9 (4): 1133–43. PMID 8134115.
- ^ Takai T, Nishita Y, Iguchi-Ariga SM, Ariga H (1994). "Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity". Nucleic Acids Res. 22 (25): 5576–81. doi:10.1093/nar/22.25.5576. PMC 310119. PMID 7838710.
- ^ a b "Entrez Gene: RBMS1 RNA binding motif, single stranded interacting protein 1".
- ^ Niki T, Galli I, Ariga H, Iguchi-Ariga SM (June 2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Lett. 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. PMID 10869558. S2CID 31594271.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Haigermoser C, Fujimoto M, Iguchi-Ariga SM, Ariga H (1996). "Cloning and characterization of the genomic DNA of the human MSSP genes". Nucleic Acids Res. 24 (19): 3846–57. doi:10.1093/nar/24.19.3846. PMC 146151. PMID 8871567.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
PDB gallery
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1x4e: Solution structure of RRM domain in RNA binding motif, single-stranded interacting protein 2 -
1x5o: Solution structure of RRM domain in RNA binding motif, single-stranded interacting protein 1 |
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