RAPGEF2 |
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Identifiers |
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Aliases | RAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2, RAGEF |
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External IDs | OMIM: 609530; MGI: 2659071; HomoloGene: 35477; GeneCards: RAPGEF2; OMA:RAPGEF2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q32.1 | Start | 159,103,013 bp[1] |
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End | 159,360,174 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 E3 | Start | 78,969,823 bp[2] |
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End | 79,193,824 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- middle temporal gyrus
- endothelial cell
- frontal pole
- postcentral gyrus
- orbitofrontal cortex
- tibia
- Brodmann area 10
- Brodmann area 46
- entorhinal cortex
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| Top expressed in | - olfactory tubercle
- subdivision of hippocampus
- Region I of hippocampus proper
- subiculum
- piriform cortex
- lateral septal nucleus
- temporal lobe
- primary motor cortex
- amygdala
- anterior amygdaloid area
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - calcium ion binding
- protein binding
- diacylglycerol binding
- signal transducer activity
- guanyl-nucleotide exchange factor activity
- WW domain binding
- phosphatidic acid binding
- PDZ domain binding
- cAMP binding
- cGMP binding
- beta-1 adrenergic receptor binding
- GTPase activator activity
| Cellular component | - cell-cell junction
- endocytic vesicle
- synapse
- integral component of plasma membrane
- apical plasma membrane
- bicellular tight junction
- endosome
- cell junction
- neuron projection
- neuronal cell body
- cytoplasm
- cytosol
- late endosome
- membrane
- plasma membrane
- perinuclear region of cytoplasm
- protein-containing complex
- intracellular anatomical structure
| Biological process | - positive regulation of ERK1 and ERK2 cascade
- brain-derived neurotrophic factor receptor signaling pathway
- cellular response to cGMP
- ventricular system development
- positive regulation of protein binding
- forebrain neuron development
- regulation of cell junction assembly
- protein localization to plasma membrane
- positive regulation of neuron projection development
- adenylate cyclase-activating adrenergic receptor signaling pathway
- nervous system development
- neuron migration
- neuropeptide signaling pathway
- multicellular organism development
- G protein-coupled receptor signaling pathway
- negative regulation of melanin biosynthetic process
- cellular response to nerve growth factor stimulus
- cell differentiation
- positive regulation of cAMP-mediated signaling
- intracellular signal transduction
- cellular response to cAMP
- nerve growth factor signaling pathway
- regulation of cell population proliferation
- Rap protein signal transduction
- small GTPase mediated signal transduction
- negative regulation of cell population proliferation
- blood vessel development
- positive regulation of dendritic cell apoptotic process
- positive regulation of vasculogenesis
- microvillus assembly
- negative regulation of dendrite morphogenesis
- regulation of synaptic plasticity
- neuron projection development
- establishment of endothelial intestinal barrier
- positive regulation of cAMP-dependent protein kinase activity
- positive regulation of neuron migration
- positive regulation of protein kinase activity
- establishment of endothelial barrier
- signal transduction
- MAPK cascade
- positive regulation of GTPase activity
- cAMP-mediated signaling
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_014247 NM_001351724 NM_001351725 NM_001351726 NM_001351727
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NM_001351728 NM_001394067 |
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RefSeq (protein) | NP_055062 NP_001338653 NP_001338654 NP_001338655 NP_001338656
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NP_001338657 |
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Location (UCSC) | Chr 4: 159.1 – 159.36 Mb | Chr 3: 78.97 – 79.19 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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