RAB6B
Protein-coding gene in the species Homo sapiens
RAB6B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | RAB6B, member RAS oncogene family | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 615852; MGI: 107283; HomoloGene: 39749; GeneCards: RAB6B; OMA:RAB6B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000154917 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032549 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RAB6B RAB6B, member RAS oncogene family".
Further reading
- Chen D, Guo J, Gahl WA (January 1997). "RAB GTPases expressed in human melanoma cells". Biochimica et Biophysica Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
- Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
- Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Garcia-Saez I, Tcherniuk S, Kozielski F (July 2006). "The structure of human neuronal Rab6B in the active and inactive form". Acta Crystallographica Section D. 62 (Pt 7): 725–33. doi:10.1107/S0907444906015319. PMID 16790928.
- Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (October 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.
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PDB gallery
- 1yzq: GppNHp-Bound Rab6 GTPase
- 2fe4: The crystal structure of human neuronal Rab6B in its inactive GDP-bound form
- 2ffq: The crystal structure of human neuronal Rab6B in its active GTPgS-bound form
- 2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution
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