RAB6B

Protein-coding gene in the species Homo sapiens

RAB6B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2E9S, 2FE4, 2FFQ

Identifiers

Aliases

RAB6B, member RAS oncogene family

External IDs

OMIM: 615852; MGI: 107283; HomoloGene: 39749; GeneCards: RAB6B; OMA:RAB6B - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q22.1	Start	133,824,235 bp^[1]
Band	3q22.1	End	133,895,882 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 F1\|9 54.88 cM	Start	102,988,986 bp^[2]
Band	9 F1\|9 54.88 cM	End	103,062,475 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lateral nuclear group of thalamus

frontal pole

Brodmann area 10

middle temporal gyrus

pons

Pars compacta

Brodmann area 46

orbitofrontal cortex

superior frontal gyrus

superior vestibular nucleus

Top expressed in

substantia nigra

trigeminal ganglion

medial dorsal nucleus

piriform cortex

prefrontal cortex

primary motor cortex

medial geniculate nucleus

pontine nuclei

lateral geniculate nucleus

temporal lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding myosin V binding protein binding GTPase activity
Cellular component	Golgi membrane membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment cytosol Golgi apparatus presynapse intracellular anatomical structure
Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum protein transport intra-Golgi vesicle-mediated transport retrograde transport, endosome to Golgi vesicle-mediated transport intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51560


270192

Ensembl


ENSG00000154917


ENSMUSG00000032549

UniProt


Q9NRW1


P61294

RefSeq (mRNA)


NM_016577 NM_001363953


NM_173781

RefSeq (protein)


NP_057661 NP_001350882


NP_776142

Location (UCSC)

Chr 3: 133.82 – 133.9 Mb

Chr 9: 102.99 – 103.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032549 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAB6B RAB6B, member RAS oncogene family".

Chen D, Guo J, Gahl WA (January 1997). "RAB GTPases expressed in human melanoma cells". Biochimica et Biophysica Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Garcia-Saez I, Tcherniuk S, Kozielski F (July 2006). "The structure of human neuronal Rab6B in the active and inactive form". Acta Crystallographica Section D. 62 (Pt 7): 725–33. doi:10.1107/S0907444906015319. PMID 16790928.
Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (October 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.

PDB gallery

1yzq: GppNHp-Bound Rab6 GTPase
2fe4: The crystal structure of human neuronal Rab6B in its inactive GDP-bound form
2ffq: The crystal structure of human neuronal Rab6B in its active GTPgS-bound form
2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution