Prostaglandin E
- G02AD (WHO)
- 11042-70-9
- none
Prostaglandin E is a family of naturally occurring prostaglandins that are used as medications.
Types include:
- Prostaglandin E1 also known as alprostadil
- Prostaglandin E2 also known as dinoprostone
Both types are on the World Health Organization's List of Essential Medicines.[1]
Prostaglandin E play an important role in thermoregulation of the human brain. Decreased formation of prostaglandin E through inhibition of cyclooxygenase is the basis for the antipyretic of nonsteroidal anti-inflammatory drugs (NSAIDs).
References
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
External links
- "Alprostadil". Drug Information Portal. U.S. National Library of Medicine.
- "Dinoprostone". Drug Information Portal. U.S. National Library of Medicine.
- Prostaglandins+E at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Eicosanoids
- Arachidonic acid
Prostaglandins (PG) |
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Thromboxanes (TX) |
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Precursor |
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Initial |
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SRS-A |
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Precursor |
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Eoxins |
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- Lipoxins (LX) (A4, B4)
- Virodhamine
- bronchoconstriction
- PGD2
- TXA2
- LTC4
- LTD4
- LTE4
- vasoconstriction
- PGF2α
- TXA2
- TXB2
- vasodilation
- PGE2
- PGI2
- LTC4
- LTD4
- LTE4
- platelets: induce
- TXA2
- inhibit
- PGD2
- PGI2
- leukocytes: induce
- TXA2
- LTB4
- inhibit
- PGD2
- PGE2
- fever stimulation:
- PGE2
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
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