Plakophilin-3

Protein-coding gene in the species Homo sapiens
PKP3
Identifiers
AliasesPKP3, plakophilin 3
External IDsOMIM: 605561; MGI: 1891830; HomoloGene: 5200; GeneCards: PKP3; OMA:PKP3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PKP3
Genomic location for PKP3
Band11p15.5Start392,614 bp[1]
End404,908 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PKP3
Genomic location for PKP3
Band7|7 F5Start140,658,131 bp[2]
End140,670,423 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • mucosa of pharynx

  • human penis

  • skin of arm

  • mucosa of transverse colon

  • mucosa of ileum

  • nipple

  • vulva

  • gums
Top expressed in
  • lip

  • epidermis

  • hair follicle

  • esophagus

  • skin of external ear

  • corneal stroma

  • skin of abdomen

  • skin of back

  • saccule

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • alpha-catenin binding
  • cell adhesion molecule binding
  • cadherin binding involved in cell-cell adhesion
  • RNA binding
  • protein binding
  • enzyme binding
  • translation regulator activity
  • cadherin binding
Cellular component
  • desmosome
  • nucleus
  • cell-cell junction
  • cornified envelope
  • nucleoplasm
  • plasma membrane
  • cell junction
  • messenger ribonucleoprotein complex
  • cytoplasm
Biological process
  • desmosome assembly
  • cell adhesion
  • keratinization
  • cornification
  • regulation of translation
  • positive regulation of gene expression
  • negative regulation of mRNA catabolic process
  • protein localization to plasma membrane
  • cell-cell adhesion
  • cell-cell junction assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11187

56460

Ensembl

ENSG00000184363

ENSMUSG00000054065

UniProt

Q9Y446

Q9QY23

RefSeq (mRNA)

NM_007183
NM_001303029

NM_001162924
NM_019762

RefSeq (protein)

NP_001289958
NP_009114

NP_001156396
NP_062736

Location (UCSC)Chr 11: 0.39 – 0.4 MbChr 7: 140.66 – 140.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[5][6]

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[6]

Interactions

PKP3 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184363 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054065 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
  6. ^ a b "Entrez Gene: PKP3 plakophilin 3".
  7. ^ a b c d Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. hdl:1854/LU-210987. PMC 2172904. PMID 12707304.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bonné S, van Hengel J, Nollet F, Kools P, van Roy F (1999). "Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells". J. Cell Sci. 112 (14): 2265–76. doi:10.1242/jcs.112.14.2265. hdl:1854/LU-113819. PMID 10381383.
  • Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis". J. Cell Sci. 113 (13): 2471–83. doi:10.1242/jcs.113.13.2471. PMID 10852826.
  • Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
  • Papagerakis S, Shabana AH, Depondt J, Gehanno P, Forest N (2003). "Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters". Hum. Pathol. 34 (6): 565–72. doi:10.1016/S0046-8177(03)00174-6. PMID 12827610.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke WW (2006). "Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules". Mol. Biol. Cell. 17 (3): 1388–98. doi:10.1091/mbc.E05-08-0708. PMC 1382326. PMID 16407409.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonné S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007). "The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression". FEBS Lett. 581 (8): 1617–24. doi:10.1016/j.febslet.2007.03.026. PMC 2938730. PMID 17391671.


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