Phosphatidylcholine—sterol O-acyltransferase
phosphatidylcholine-sterol O-acyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.3.1.43 | ||||||||
CAS no. | 9031-14-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction
- phosphatidylcholine + a sterol 1-acylglycerophosphocholine + a sterol ester
Thus, the two substrates of this enzyme are phosphatidylcholine and sterol, whereas its two products are 1-acylglycerophosphocholine and sterol ester.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:sterol O-acyltransferase. Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT (lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
- Bartlett K, Keat MJ, Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry. 13: 1107–1113. doi:10.1016/0031-9422(74)80083-X.
- Buckley JT, Halasa LN, MacIntyre S (1982). "Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase". J. Biol. Chem. 257 (6): 3320–5. PMID 7061477.
- Glomset JA (1968). "The plasma lecithins:cholesterol acyltransferase reaction". J. Lipid Res. 9 (2): 155–67. PMID 4868699.
- Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal. 16: 219–72. doi:10.1002/9780470110348.ch4. PMID 4877146.
- v
- t
- e
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Histone acetyltransferase
- Citrate synthase
- Decylcitrate synthase
- Citrate (Re)-synthase
- Decylhomocitrate synthase
- 2-methylcitrate synthase
- 2-ethylmalate synthase
- 3-ethylmalate synthase
- ATP citrate lyase
- Malate synthase
- HMG-CoA synthase
- 2-hydroxyglutarate synthase
- 3-propylmalate synthase
- 2-isopropylmalate synthase
- Homocitrate synthase
- Sulfoacetaldehyde acetyltransferase