PSMG1

Protein found in humans
PSMG1
Identifiers
AliasesPSMG1, C21LRP, DSCR2, LRPC21, PAC-1, PAC1, proteasome assembly chaperone 1
External IDsOMIM: 605296; MGI: 1860263; HomoloGene: 2759; GeneCards: PSMG1; OMA:PSMG1 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for PSMG1
Genomic location for PSMG1
Band21q22.2Start39,174,769 bp[1]
End39,183,488 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for PSMG1
Genomic location for PSMG1
Band16|16 C4Start95,781,133 bp[2]
End95,792,160 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • gonad

  • rectum

  • endometrium

  • mucosa of transverse colon

  • body of pancreas

  • mucosa of esophagus

  • right adrenal gland

  • right adrenal cortex
Top expressed in
  • otic placode

  • saccule

  • otic vesicle

  • primitive streak

  • epiblast

  • embryo

  • endocardial cushion

  • embryo

  • abdominal wall

  • left lobe of liver
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • proteasome binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • endoplasmic reticulum
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • cerebellar granule cell precursor proliferation
  • proteasome assembly
  • proteasome core complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8624

56088

Ensembl

ENSG00000183527

ENSMUSG00000022913

UniProt

O95456

Q9JK23

RefSeq (mRNA)

NM_001261824
NM_003720
NM_203433
NM_001320795

NM_019537

RefSeq (protein)

NP_001248753
NP_001307724
NP_003711
NP_982257

NP_062410

Location (UCSC)Chr 21: 39.17 – 39.18 MbChr 16: 95.78 – 95.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.[5][6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183527 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022913 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R (Jul 2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation". Biochem Biophys Res Commun. 272 (1): 156–63. doi:10.1006/bbrc.2000.2726. PMID 10872820.
  6. ^ Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (Dec 2006). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes". Mol Cell. 24 (6): 977–84. doi:10.1016/j.molcel.2006.11.015. PMID 17189198.
  7. ^ "Entrez Gene: DSCR2 Down syndrome critical region gene 2".

Further reading

  • Vidal-Taboada JM, Sanz S, Egeo A, et al. (1998). "Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein". Biochem. Biophys. Res. Commun. 250 (3): 547–54. doi:10.1006/bbrc.1998.9352. PMID 9784380.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Possik PA, Sommer CA, Issa Hori J, et al. (2005). "DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells". European Journal of Histochemistry. 48 (3): 267–72. PMID 15590417.
  • Vesa J, Brown Y, Greenfield D, Korenberg JR (2005). "Molecular and cellular characterization of the Down syndrome critical region protein 2". Biochem. Biophys. Res. Commun. 328 (1): 235–42. doi:10.1016/j.bbrc.2004.09.226. PMID 15670775.
  • Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes". Nature. 437 (7063): 1381–5. Bibcode:2005Natur.437.1381H. doi:10.1038/nature04106. PMID 16251969. S2CID 4424913.


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