PFKFB2

Protein-coding gene in the species Homo sapiens
PFKFB2
Identifiers
AliasesPFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDsOMIM: 171835; MGI: 107815; HomoloGene: 88554; GeneCards: PFKFB2; OMA:PFKFB2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PFKFB2
Genomic location for PFKFB2
Band1q32.1Start207,034,366 bp[1]
End207,081,024 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PFKFB2
Genomic location for PFKFB2
Band1|1 E4Start130,616,919 bp[2]
End130,656,990 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • oocyte

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • gastrocnemius muscle

  • rectum

  • apex of heart

  • duodenum

  • anterior pituitary

  • left ventricle
Top expressed in
  • neural layer of retina

  • spermatocyte

  • islet of Langerhans

  • spermatid

  • superior frontal gyrus

  • pineal gland

  • lumbar subsegment of spinal cord

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • kinase activity
  • protein binding
  • catalytic activity
  • fructose-2,6-bisphosphate 2-phosphatase activity
  • hydrolase activity
  • ATP binding
  • protein kinase binding
  • 6-phosphofructo-2-kinase activity
  • kinase binding
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
  • nucleoplasm
Biological process
  • lactate metabolic process
  • glycolytic process
  • phosphorylation
  • fructose metabolic process
  • response to glucose
  • positive regulation of glucokinase activity
  • fructose 2,6-bisphosphate metabolic process
  • pyruvate metabolic process
  • glucose catabolic process
  • metabolism
  • positive regulation of insulin secretion
  • dephosphorylation
  • carbohydrate phosphorylation
  • positive regulation of glycolytic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5208

18640

Ensembl

ENSG00000123836

ENSMUSG00000026409

UniProt

O60825

P70265

RefSeq (mRNA)

NM_001018053
NM_006212

NM_001162415
NM_001162416
NM_008825
NM_001368843

RefSeq (protein)

NP_001018063
NP_006203

NP_001155887
NP_001155888
NP_032851
NP_001355772

Location (UCSC)Chr 1: 207.03 – 207.08 MbChr 1: 130.62 – 130.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.[5]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[5]

Interactions

PFKFB2 has been shown to interact with YWHAQ.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123836 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026409 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2".
  6. ^ Pozuelo Rubio M, Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. 22 (14). England: 3514–23. doi:10.1093/emboj/cdg363. ISSN 0261-4189. PMC 165633. PMID 12853467.

Further reading

  • Rider MH, Vandamme J, Lebeau E, et al. (1992). "The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing". Biochem. J. 285 (2): 405–11. doi:10.1042/bj2850405. PMC 1132803. PMID 1322130.
  • Hilliker CE, Darville MI, Aly MS, et al. (1991). "Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization". Genomics. 10 (4): 867–73. doi:10.1016/0888-7543(91)90174-D. PMID 1655632.
  • Goldmuntz EA, Remmers EF, Zha H, et al. (1994). "Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5". Mamm. Genome. 4 (11): 670–5. doi:10.1007/BF00360905. PMID 7904197. S2CID 1892799.
  • Hirata T, Kato M, Okamura N, et al. (1998). "Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines". Biochem. Biophys. Res. Commun. 242 (3): 680–4. doi:10.1006/bbrc.1997.8024. PMID 9464277.
  • Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S (1998). "Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)". Eur. J. Biochem. 254 (1): 103–10. doi:10.1046/j.1432-1327.1998.2540103.x. PMID 9652401.
  • Hirata T, Watanabe M, Miura S, et al. (2001). "Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues". Biosci. Biotechnol. Biochem. 64 (10): 2047–52. doi:10.1271/bbb.64.2047. PMID 11129574. S2CID 38413244.
  • Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res. 87 (2): 190–5. doi:10.1016/S0169-328X(01)00014-6. PMID 11245921.
  • Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
  • Baltrusch S, Lenzen S, Okar DA, et al. (2001). "Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner". J. Biol. Chem. 276 (47): 43915–23. doi:10.1074/jbc.M105470200. PMID 11522786.
  • Marsin AS, Bouzin C, Bertrand L, Hue L (2002). "The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase". J. Biol. Chem. 277 (34): 30778–83. doi:10.1074/jbc.M205213200. PMID 12065600.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pozuelo Rubio M, Peggie M, Wong BH, et al. (2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. 22 (14): 3514–23. doi:10.1093/emboj/cdg363. PMC 165633. PMID 12853467.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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Glycolysis
Gluconeogenesis only
to oxaloacetate:
from lactate (Cori cycle):
from alanine (Alanine cycle):
from glycerol:
Regulatory
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