OBSL1

Protein-coding gene in the species Homo sapiens
OBSL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CPC, 2E6P, 2E6Q, 2LU7, 2LVC, 2WP3, 2WWK, 2WWM, 3KNB

Identifiers
AliasesOBSL1, obscurin like 1, obscurin like cytoskeletal adaptor 1
External IDsOMIM: 610991; MGI: 2138628; HomoloGene: 28013; GeneCards: OBSL1; OMA:OBSL1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for OBSL1
Genomic location for OBSL1
Band2q35Start219,550,728 bp[1]
End219,571,859 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for OBSL1
Genomic location for OBSL1
Band1|1 C4Start75,455,954 bp[2]
End75,483,096 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • left ovary

  • right ovary

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right adrenal cortex

  • right uterine tube

  • apex of heart

  • right hemisphere of cerebellum
Top expressed in
  • yolk sac

  • internal carotid artery

  • external carotid artery

  • fossa

  • muscle of thigh

  • condyle

  • vas deferens

  • renal corpuscle

  • genital tubercle

  • medullary collecting duct
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • cytoskeletal anchor activity
  • protein binding
  • structural constituent of muscle
  • actin filament binding
  • muscle alpha-actinin binding
  • structural molecule activity conferring elasticity
Cellular component
  • Z discdkac
  • 3M complex
  • intercalated disc
  • M band
  • centrosome
  • microtubule organizing center
  • cytoskeleton
  • cytoplasm
  • Golgi apparatus
  • perinuclear region of cytoplasm
  • muscle myosin complex
  • cytosol
  • striated muscle thin filament
  • sarcomere
Biological process
  • protein localization to Golgi apparatus
  • cardiac myofibril assembly
  • microtubule cytoskeleton organization
  • cytoskeleton organization
  • regulation of mitotic nuclear division
  • positive regulation of dendrite morphogenesis
  • Golgi organization
  • striated muscle contraction
  • actin filament organization
  • sarcomere organization
  • striated muscle myosin thick filament assembly
  • post-translational protein modification
  • muscle contraction
  • skeletal muscle thin filament assembly
  • skeletal muscle myosin thick filament assembly
  • cardiac muscle tissue morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23363

98733

Ensembl

ENSG00000124006

ENSMUSG00000026211

UniProt

O75147

D3YYU8

RefSeq (mRNA)

NM_001173408
NM_001173431
NM_015311

NM_178884
NM_001310679

RefSeq (protein)

NP_001166879
NP_001166902
NP_056126

NP_001297608
NP_849215
NP_001390042
NP_001390043

Location (UCSC)Chr 2: 219.55 – 219.57 MbChr 1: 75.46 – 75.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124006 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026211 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ "Entrez Gene: OBSL1 obscurin-like 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Geisler SB, Robinson D, Hauringa M, et al. (2007). "Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin". Genomics. 89 (4): 521–31. doi:10.1016/j.ygeno.2006.12.004. PMC 1885211. PMID 17289344.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
  • OMIM entries on 3-M syndrome
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Obscurin-like protein 1 (OBSL1)
  • v
  • t
  • e
  • 2cpc: Solution structure of RSGI RUH-030, an Ig like domain from human cDNA
    2cpc: Solution structure of RSGI RUH-030, an Ig like domain from human cDNA


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