NT5C1A

Protein-coding gene in the species Homo sapiens
NT5C1A
Identifiers
AliasesNT5C1A, CN-I, CN-IA, CN1, CN1A, CNI, 5'-nucleotidase, cytosolic IA
External IDsOMIM: 610525; MGI: 2155700; HomoloGene: 57173; GeneCards: NT5C1A; OMA:NT5C1A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for NT5C1A
Genomic location for NT5C1A
Band1p34.2Start39,651,229 bp[1]
End39,672,107 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for NT5C1A
Genomic location for NT5C1A
Band4|4 D2.2Start123,095,297 bp[2]
End123,110,068 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • testicle

  • muscle of thigh

  • apex of heart

  • striated muscle tissue

  • skeletal muscle tissue

  • right atrium

  • right auricle

  • left ventricle

  • cerebellar cortex
Top expressed in
  • muscle of thigh

  • skeletal muscle tissue

  • quadriceps femoris muscle

  • adrenal gland

  • cerebellum

  • cerebellar cortex

  • hippocampus proper

  • dentate gyrus of hippocampal formation granule cell

  • circulatory system

  • heart
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • hydrolase activity
  • magnesium ion binding
  • protein binding
  • 5'-nucleotidase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • nucleoside metabolic process
  • adenosine metabolic process
  • purine nucleotide catabolic process
  • nucleotide metabolic process
  • pyrimidine nucleoside catabolic process
  • dephosphorylation
  • purine nucleoside monophosphate catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84618

230718

Ensembl

ENSG00000116981

ENSMUSG00000054958

UniProt

Q9BXI3

A3KFX0

RefSeq (mRNA)

NM_032526

NM_001085502

RefSeq (protein)

NP_115915

NP_001078971

Location (UCSC)Chr 1: 39.65 – 39.67 MbChr 4: 123.1 – 123.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

5'-nucleotidase, cytosolic IA is a protein that in humans is encoded by the NT5C1A gene.[5]

Function

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116981 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054958 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: 5'-nucleotidase, cytosolic IA".

Further reading

  • Hunsucker SA, Spychala J, Mitchell BS (2001). "Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance". J. Biol. Chem. 276 (13): 10498–504. doi:10.1074/jbc.M011218200. PMID 11133996.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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