Molybdocene dichloride
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Names | |||
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IUPAC name dichlorobis(η5-cyclopentadienyl)molybdenum(IV) | |||
Other names molybdocene dichloride, molybdenocene dichloride, dichloridobis(cyclopentadienyl)molybdenum(IV) | |||
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3D model (JSmol) |
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ECHA InfoCard | 100.159.644 | ||
PubChem CID |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |||
Chemical formula | C10H10Cl2Mo | ||
Molar mass | 297.04 g·mol−1 | ||
Appearance | greenish-brown powder | ||
Solubility in water | insoluble, moisture sensitive | ||
Hazards | |||
Safety data sheet (SDS) | [1] | ||
Related compounds | |||
Related compounds | Ferrocene Zirconocene dichloride Vanadocene dichloride Niobocene dichloride Titanocene dichloride Tantalocene dichloride | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Molybdocene dichloride is the organomolybdenum compound with the formula (η5-C5H5)2MoCl2 and IUPAC name dichlorobis(η5-cyclopentadienyl)molybdenum(IV), and is commonly abbreviated as Cp2MoCl2. It is a brownish-green air- and moisture-sensitive powder. In the research laboratory, it is used to prepare many derivatives.
Preparation and structure
The compound is prepared from molybdocene dihydride by treatment with chloroform:[2]
- (C5H5)2MoH2 + 2 CHCl3 → (C5H5)2MoCl2 + 2 CH2Cl2
The compound adopts a "clamshell" structure where the Cp rings are not parallel, the average Cp(centroid)-M-Cp angle being 130.6°. The two chloride ligands are cis, the Cl-Mo-Cl angle of 82° being narrower than in niobocene dichloride (85.6°), which in turn is less than in zirconacene dichloride (92.1°). This trend helped to establish the orientation of the HOMO in this class of complex.[3]
Uses
Unlike the titanocene and zirconacene derivatives, the molybdocene compounds have yielded no commercial applications.
All metallocene dihalides exhibit some anti-cancer activity,[4] but these have not yielded useful compounds in the clinic.[5]
References
- ^ "42-0100 Molybdenum " Bis(cyclopentadienyl)molybdenum dichloride, 99%". Strem Chemicals. 27 July 2011. Retrieved 5 February 2012.
- ^ Silavwe, Ned D.; Castellani, Michael P.; Tyler, David R. (1992). "Bis(η5-Cyclopentadienyl)Molybdenum(IV) Complexes". Inorganic Syntheses. Vol. 29. pp. 204–211. doi:10.1002/9780470132609.ch50. ISBN 9780470132609.
- ^ K. Prout, T. S. Cameron, R. A. Forder, and in parts S. R. Critchley, B. Denton and G. V. Rees "The crystal and molecular structures of bent bis-π-cyclopentadienyl-metal complexes: (a) bis-π-cyclopentadienyldibromorhenium(V) tetrafluoroborate, (b) bis-π-cyclopentadienyldichloromolybdenum(IV), (c) bis-π-cyclopentadienylhydroxomethylaminomolybdenum(IV) hexafluorophosphate, (d) bis-π-cyclopentadienylethylchloromolybdenum(IV), (e) bis-π-cyclopentadienyldichloroniobium(IV), (f) bis-π-cyclopentadienyldichloromolybdenum(V) tetrafluoroborate, (g) μ-oxo-bis[bis-π-cyclopentadienylchloroniobium(IV)] tetrafluoroborate, (h) bis-π-cyclopentadienyldichlorozirconium" Acta Crystallogr. 1974, volume B30, pp. 2290–2304. doi:10.1107/S0567740874007011
- ^ Roat-Malone, R. M. (2007). Bioinorganic Chemistry: A Short Course (2nd ed.). John Wiley & Sons. pp. 19–20. ISBN 978-0-471-76113-6.
- ^ Waern, J. B.; Dillon, C. T.; Harding, M. M. (2005). "Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride". J. Med. Chem. 48 (6): 2093–2099. doi:10.1021/jm049585o. PMID 15771451.
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CpH | He | ||||||||||||||||||||
LiCp | Be | B | CpMe | N | C5H4O | F | Ne | ||||||||||||||
NaCp | MgCp2 | Al | Si | P | S | Cl | Ar | ||||||||||||||
K | CaCp2 | ScCp3 | TiCp2Cl2 (TiCp2Cl)2 | VCp2 VCpCh | CrCp2 (CrCp(CO)3)2 | MnCp2 | FeCp2 Fe(η5-C5H4Li)2 | CoCp2 CoCp(CO)2 | NiCp2 | Cu | Zn | Ga | Ge | As | Se | Br | Kr | ||||
Rb | Sr | Y(C5H5)3 | ZrCp2Cl2 ZrCp2ClH | NbCp2Cl2 | MoCp2H2 MoCp2Cl2 | Tc | RuCp2 RuCp(PPh3)2Cl | RhCp2 | PdCp(C3H5) | Ag | Cd | InCp | SnCp2 | Sb | Te | I | Xe | ||||
Cs | Ba | * | LuCp3 | HfCp2Cl2 | Ta | (WCp(CO)3)2 | ReCp2H | OsCp2 | IrCp2 | Pt | Au | Hg | TlCp | PbCp2 | Bi | Po | At | Rn | |||
Fr | Ra | ** | Lr | Rf | Db | Sg | Bh | HsCp2 | Mt | Ds | Rg | Cn | Nh | Fl | Mc | Lv | Ts | Og | |||
* | LaCp3 | CeCp3 | PrCp3 | NdCp3 | PmCp3 | SmCp3 | Eu | Gd | Tb | DyCp3 | Ho | ErCp3 | TmCp3 | YbCp3 | |||||||
** | Ac | ThCp3 ThCp4 | Pa | UCp4 | Np | Pu | Am | Cm | Bk | Cf | Es | Fm | Md | No |