MEPE

Protein-coding gene in the species Homo sapiens
MEPE
Identifiers
AliasesMEPE, OF45, matrix extracellular phosphoglycoprotein
External IDsOMIM: 605912 MGI: 2137384 HomoloGene: 10623 GeneCards: MEPE
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MEPE
Genomic location for MEPE
Band4q22.1Start87,821,398 bp[1]
End87,846,814 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for MEPE
Genomic location for MEPE
Band5|5 E5Start104,473,195 bp[2]
End104,486,477 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • periodontal fiber

  • trabecular bone

  • cingulate gyrus

  • Brodmann area 23

  • Brodmann area 9

  • prefrontal cortex

  • middle temporal gyrus

  • superior frontal gyrus

  • postcentral gyrus
Top expressed in
  • body of femur

  • cochlea

  • fossa

  • vestibular labyrinth

  • sexually immature organism
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • extracellular matrix structural constituent
  • protein binding
  • extracellular matrix protein binding
Cellular component
  • extracellular region
  • endoplasmic reticulum lumen
  • extracellular matrix
Biological process
  • skeletal system development
  • biomineral tissue development
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56955

94111

Ensembl

ENSG00000152595

ENSMUSG00000053863

UniProt

Q9NQ76

Q8K4L6

RefSeq (mRNA)
NM_001184694
NM_001184695
NM_001184696
NM_001184697
NM_001291183

NM_020203

NM_053172

RefSeq (protein)
NP_001171623
NP_001171624
NP_001171625
NP_001171626
NP_001278112

NP_064588

NP_444402

Location (UCSC)Chr 4: 87.82 – 87.85 MbChr 5: 104.47 – 104.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Osteoregulin
Identifiers
SymbolOsteoregulin
PfamPF07175
InterProIPR009837
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.[5][6] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.[7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.
  6. ^ "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".
  7. ^ Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

Further reading

  • Quarles LD (2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization". Am. J. Physiol. Endocrinol. Metab. 285 (1): E1–9. doi:10.1152/ajpendo.00016.2003. PMID 12791601.
  • Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
  • Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
  • Jain A, Fedarko NS, Collins MT, et al. (2004). "Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density". J. Clin. Endocrinol. Metab. 89 (8): 4158–61. doi:10.1210/jc.2003-032031. PMID 15292364.
  • Nampei A, Hashimoto J, Hayashida K, et al. (2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone". J. Bone Miner. Metab. 22 (3): 176–84. doi:10.1007/s00774-003-0468-9. PMID 15108058. S2CID 13194013.
  • MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21". Connect. Tissue Res. 43 (2–3): 320–30. doi:10.1080/713713461. PMID 12489176.
  • Argiro L, Desbarats M, Glorieux FH, Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone". Genomics. 74 (3): 342–51. doi:10.1006/geno.2001.6553. PMID 11414762.
This article incorporates text from the public domain Pfam and InterPro: IPR009837


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