MORF4L2

Protein-coding gene in the species Homo sapiens
MORF4L2
Identifiers
AliasesMORF4L2, MORFL2, MRGX, mortality factor 4 like 2
External IDsOMIM: 300409; MGI: 1927167; HomoloGene: 22710; GeneCards: MORF4L2; OMA:MORF4L2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for MORF4L2
Genomic location for MORF4L2
BandXq22.2Start103,675,496 bp[1]
End103,688,158 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for MORF4L2
Genomic location for MORF4L2
BandX|X F1Start135,633,691 bp[2]
End135,644,439 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Epithelium of choroid plexus

  • caput epididymis

  • bronchial epithelial cell

  • pons

  • tail of epididymis

  • postcentral gyrus

  • Brodmann area 23

  • seminal vesicula

  • corpus epididymis
Top expressed in
  • yolk sac

  • placenta

  • mesencephalon

  • neural tube

  • lens

  • epiblast

  • islet of Langerhans

  • uterus

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • plasma membrane
  • nucleolus
  • nucleus
  • nucleoplasm
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
Biological process
  • histone H2A acetylation
  • chromatin remodeling
  • regulation of growth
  • regulation of transcription, DNA-templated
  • histone deacetylation
  • DNA repair
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • positive regulation of striated muscle cell differentiation
  • cellular response to DNA damage stimulus
  • histone H4 acetylation
  • chromatin organization
  • histone acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9643

56397

Ensembl

ENSG00000123562

ENSMUSG00000031422

UniProt

Q15014

Q9R0Q4

RefSeq (mRNA)
NM_012286
NM_001142418
NM_001142419
NM_001142420
NM_001142421

NM_001142422
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142427
NM_001142428
NM_001142429
NM_001142430
NM_001142431
NM_001142432

NM_001168225
NM_001168226
NM_001168227
NM_001168228
NM_001168229

NM_001168230
NM_019768

RefSeq (protein)
NP_001135890
NP_001135891
NP_001135892
NP_001135893
NP_001135894

NP_001135895
NP_001135896
NP_001135897
NP_001135898
NP_001135899
NP_001135900
NP_001135901
NP_001135902
NP_001135903
NP_001135904
NP_036418

NP_001161697
NP_001161698
NP_001161699
NP_001161700
NP_001161701

NP_001161702
NP_062742

Location (UCSC)Chr X: 103.68 – 103.69 MbChr X: 135.63 – 135.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123562 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031422 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.
  6. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  7. ^ "Entrez Gene: MORF4L2 mortality factor 4 like 2".

Further reading

  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID 11988016. S2CID 26659745.
  • Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
  • Tominaga K, Leung JK, Rookard P, et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". J. Biol. Chem. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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