LMBR1L

Protein-coding gene in humans
LMBR1L
Identifiers
AliasesLMBR1L, LIMR, limb development membrane protein 1 like
External IDsOMIM: 610007; MGI: 1289247; HomoloGene: 10011; GeneCards: LMBR1L; OMA:LMBR1L - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for LMBR1L
Genomic location for LMBR1L
Band12q13.12Start49,097,136 bp[1]
End49,110,900 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for LMBR1L
Genomic location for LMBR1L
Band15 F1|15 55.1 cMStart98,801,798 bp[2]
End98,816,112 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • right uterine tube

  • anterior pituitary

  • left ovary

  • gastric mucosa

  • body of uterus

  • tibial nerve

  • right hemisphere of cerebellum

  • right ovary
Top expressed in
  • neural layer of retina

  • granulocyte

  • spermatid

  • spermatocyte

  • lip

  • yolk sac

  • seminiferous tubule

  • thymus

  • ventricular zone

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • transmembrane signaling receptor activity
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
Biological process
  • endocytosis
  • receptor-mediated endocytosis
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55716

74775

Ensembl

ENSG00000139636

ENSMUSG00000022999

UniProt

Q6UX01

Q9D1E5

RefSeq (mRNA)
NM_001300750
NM_001300751
NM_018113
NM_001352161
NM_001352162

NM_001352163
NM_001352164
NM_001352165
NM_001352166
NM_001352167
NM_001352168

NM_029098

RefSeq (protein)
NP_001287679
NP_001287680
NP_060583
NP_001339090
NP_001339091

NP_001339092
NP_001339093
NP_001339094
NP_001339095
NP_001339096
NP_001339097

NP_083374

Location (UCSC)Chr 12: 49.1 – 49.11 MbChr 15: 98.8 – 98.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein LMBR1L is a protein that in humans is encoded by the LMBR1L gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139636 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022999 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  6. ^ Wojnar P, Lechner M, Merschak P, Redl B (Jun 2001). "Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display". J Biol Chem. 276 (23): 20206–12. doi:10.1074/jbc.M101762200. PMID 11287427.
  7. ^ "Entrez Gene: LMBR1L limb region 1 homolog (mouse)-like".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wojnar P, Lechner M, Redl B (2003). "Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells". J. Biol. Chem. 278 (18): 16209–15. doi:10.1074/jbc.M210922200. PMID 12591932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Zhang Z, Kim SJ, Chowdhury B, et al. (2006). "Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion". Gene. 369: 66–71. doi:10.1016/j.gene.2005.10.027. PMID 16423471.


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