LIMD1

Protein-coding gene in the species Homo sapiens

LIMD1
Identifiers
AliasesLIMD1, LIM domains containing 1, LIM domain containing 1
External IDsOMIM: 604543; MGI: 1352502; HomoloGene: 8478; GeneCards: LIMD1; OMA:LIMD1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for LIMD1
Genomic location for LIMD1
Band3p21.31Start45,555,394 bp[1]
End45,686,341 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for LIMD1
Genomic location for LIMD1
Band9 F4|9 74.0 cMStart123,307,771 bp[2]
End123,350,617 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • mucosa of paranasal sinus

  • superficial temporal artery

  • retinal pigment epithelium

  • visceral pleura

  • synovial joint

  • pylorus

  • oral cavity

  • germinal epithelium

  • superior surface of tongue
Top expressed in
  • saccule

  • otic placode

  • otic vesicle

  • medullary collecting duct

  • triceps brachii muscle

  • spermatid

  • temporal muscle

  • decidua

  • mesenteric lymph nodes

  • internal carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • transcription corepressor activity
  • zinc ion binding
Cellular component
  • cytoplasm
  • RISC complex
  • focal adhesion
  • adherens junction
  • P-body
  • cell junction
  • nucleus
  • transcription regulator complex
  • cytosol
  • plasma membrane
  • cell-cell junction
Biological process
  • response to hypoxia
  • regulation of transcription, DNA-templated
  • phosphorylation
  • negative regulation of osteoblast differentiation
  • transcription, DNA-templated
  • positive regulation of gene silencing by miRNA
  • multicellular organism development
  • negative regulation of hippo signaling
  • gene silencing by miRNA
  • cytoskeleton organization
  • P-body assembly
  • regulation of cell shape
  • osteoblast development
  • gene silencing
  • negative regulation of transcription, DNA-templated
  • cell migration
  • negative regulation of canonical Wnt signaling pathway
  • signal transduction
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8994

29806

Ensembl

ENSG00000144791

ENSMUSG00000025239

UniProt

Q9UGP4

Q9QXD8

RefSeq (mRNA)

NM_014240

NM_013860

RefSeq (protein)

NP_055055

NP_038888

Location (UCSC)Chr 3: 45.56 – 45.69 MbChr 9: 123.31 – 123.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM domain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144791 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025239 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP (Feb 2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum Genet. 105 (6): 552–9. doi:10.1007/s004399900188. PMID 10647888.
  6. ^ "Entrez Gene: LIMD1 LIM domains containing 1".

Further reading

  • Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
  • Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. Bibcode:2004PNAS..10116531S. doi:10.1073/pnas.0407123101. PMC 534532. PMID 15542589.
  • Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
  • Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer". Cancer Genet. Cytogenet. 178 (1): 36–41. doi:10.1016/j.cancergencyto.2007.06.007. PMID 17889706.


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