LHX2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Protein_LHX2_PDB_2dmq.png/250px-Protein_LHX2_PDB_2dmq.png) |
Identifiers |
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Aliases | LHX2, LH2, hLhx2, LIM homeobox 2 |
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External IDs | OMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs |
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Gene location (Human) |
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![Chromosome 9 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Ideogram_human_chromosome_9.svg/300px-Ideogram_human_chromosome_9.svg.png) | Chr. | Chromosome 9 (human)[1] |
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| Band | 9q33.3 | Start | 124,001,670 bp[1] |
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End | 124,033,301 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 B | Start | 38,229,293 bp[2] |
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End | 38,259,745 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ventricular zone
- hair follicle
- ganglionic eminence
- sperm
- retinal pigment epithelium
- endothelial cell
- entorhinal cortex
- middle temporal gyrus
- Brodmann area 23
- amygdala
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| Top expressed in | - ventricular zone
- olfactory epithelium
- ganglionic eminence
- lip
- dentate gyrus of hippocampal formation granule cell
- septum transversum
- barrel cortex
- hand
- hippocampus proper
- hepatic diverticulum
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PBB_GE_LHX2_211219_s_at_fs.png/250px-PBB_GE_LHX2_211219_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/PBB_GE_LHX2_206140_at_fs.png/250px-PBB_GE_LHX2_206140_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - metal ion binding
- sequence-specific DNA binding
- chromatin binding
- DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
| Cellular component | - nucleus
- intracellular anatomical structure
| Biological process | - negative regulation of transcription regulatory region DNA binding
- mesoderm development
- telencephalon development
- neural tube closure
- retina development in camera-type eye
- cerebral cortex development
- transcription, DNA-templated
- axon guidance
- axon extension
- hair follicle development
- maintenance of epithelial cell apical/basal polarity
- neurogenesis
- brain development
- olfactory bulb development
- nervous system development
- dorsal/ventral pattern formation
- positive regulation of transcription, DNA-templated
- regulation of transcription, DNA-templated
- positive regulation of transcription by RNA polymerase II
- neuron differentiation
- anatomical structure formation involved in morphogenesis
- telencephalon regionalization
- transcription by RNA polymerase II
- negative regulation of gene expression, epigenetic
- negative regulation of neurogenesis
- positive regulation of neural precursor cell proliferation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 9: 124 – 124.03 Mb | Chr 2: 38.23 – 38.26 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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