Protein-coding gene in the species Homo sapiens
LAPTM4A |
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Identifiers |
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Aliases | LAPTM4A, HUMORF13, LAPTM4, MBNT, Mtrp, lysosomal protein transmembrane 4 alpha |
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External IDs | MGI: 108017; HomoloGene: 7427; GeneCards: LAPTM4A; OMA:LAPTM4A - orthologs |
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Gene location (Human) |
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![Chromosome 2 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png) | Chr. | Chromosome 2 (human)[1] |
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| Band | 2p24.1 | Start | 20,032,650 bp[1] |
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End | 20,051,628 bp[1] |
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Gene location (Mouse) |
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![Chromosome 12 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/Ideogram_house_mouse_chromosome_12.svg/260px-Ideogram_house_mouse_chromosome_12.svg.png) | Chr. | Chromosome 12 (mouse)[2] |
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| Band | 12|12 A1.1 | Start | 8,971,664 bp[2] |
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End | 8,988,742 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - seminal vesicula
- skin of hip
- germinal epithelium
- synovial joint
- urethra
- caput epididymis
- Epithelium of choroid plexus
- mucosa of paranasal sinus
- tail of epididymis
- superficial temporal artery
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| Top expressed in | - corneal stroma
- calvaria
- choroid plexus of fourth ventricle
- molar
- seminal vesicula
- extensor digitorum longus muscle
- extraocular muscle
- right lung
- lactiferous gland
- belly cord
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - endomembrane system
- integral component of membrane
- Golgi apparatus
- membrane
- lysosomal membrane
- late endosome membrane
| Biological process | | Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 20.03 – 20.05 Mb | Chr 12: 8.97 – 8.99 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Lysosomal protein transmembrane 4 alpha is a protein that in humans is encoded by the LAPTM4A gene. [5]
Function
This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000068697 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020585 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Lysosomal protein transmembrane 4 alpha". Retrieved 2017-07-03.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.