INTS11

Protein-coding gene in the species Homo sapiens


INTS11
Identifiers
AliasesINTS11, CPSF73L, INT11, RC-68, RC68, CPSF3L, cleavage and polyadenylation specific factor 3-like, integrator complex subunit 11
External IDsOMIM: 611354; MGI: 1919207; HomoloGene: 9894; GeneCards: INTS11; OMA:INTS11 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for INTS11
Genomic location for INTS11
Band1p36.33Start1,311,585 bp[1]
End1,324,687 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for INTS11
Genomic location for INTS11
Band4 E2|4 87.66 cMStart155,954,003 bp[2]
End155,973,560 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right uterine tube

  • body of uterus

  • right ovary

  • left ovary

  • canal of the cervix

  • muscle layer of sigmoid colon

  • pituitary gland

  • left uterine tube

  • fundus
Top expressed in
  • primitive streak

  • granulocyte

  • ventricular zone

  • embryo

  • morula

  • epiblast

  • medial ganglionic eminence

  • spermatocyte

  • embryo

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • hydrolase activity
  • protein binding
Cellular component
  • blood microparticle
  • integrator complex
  • nucleoplasm
  • cytosol
  • nucleus
  • cytoplasm
Biological process
  • snRNA processing
  • snRNA transcription by RNA polymerase II
  • snRNA 3'-end processing
  • regulation of RNA splicing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54973

71957

Ensembl

ENSG00000127054

ENSMUSG00000029034

UniProt

Q5TA45

Q9CWS4

RefSeq (mRNA)
NM_001256456
NM_001256460
NM_001256462
NM_001256463
NM_017871

NM_032179

NM_028020

RefSeq (protein)

NP_001243385
NP_001243389
NP_001243391
NP_001243392
NP_060341

NP_082296

Location (UCSC)Chr 1: 1.31 – 1.32 MbChr 4: 155.95 – 155.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127054 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029034 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF (Feb 2005). "A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100". Mol Cell Biol. 25 (4): 1489–500. doi:10.1128/MCB.25.4.1489-1500.2005. PMC 548002. PMID 15684398.
  6. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
  7. ^ "Entrez Gene: CPSF3L cleavage and polyadenylation specific factor 3-like".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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