Protein-coding gene in the species Homo sapiens
| INPP5F |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | INPP5F, MSTPO47, SAC2, hSAC2, MSTP007, inositol polyphosphate-5-phosphatase F |
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| External IDs | OMIM: 609389; MGI: 2141867; HomoloGene: 8962; GeneCards: INPP5F; OMA:INPP5F - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 10 (human)[1] |
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| | Band | 10q26.11 | Start | 119,726,042 bp[1] |
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| End | 119,829,147 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7|7 F3 | Start | 128,611,328 bp[2] |
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| End | 128,696,425 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - pons
- superior vestibular nucleus
- lateral nuclear group of thalamus
- Brodmann area 23
- orbitofrontal cortex
- Pars compacta
- middle temporal gyrus
- ventral tegmental area
- secondary oocyte
- Region I of hippocampus proper
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| | Top expressed in | - nucleus accumbens
- pontine nuclei
- lateral hypothalamus
- dorsal tegmental nucleus
- ventral tegmental area
- globus pallidus
- paraventricular nucleus of hypothalamus
- dorsomedial hypothalamic nucleus
- suprachiasmatic nucleus
- Region I of hippocampus proper
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - inositol monophosphate 1-phosphatase activity
- inositol monophosphate phosphatase activity
- protein homodimerization activity
- inositol monophosphate 3-phosphatase activity
- protein binding
- phosphoric ester hydrolase activity
- hydrolase activity
- inositol monophosphate 4-phosphatase activity
- phosphatidylinositol phosphate 4-phosphatase activity
- phosphatidylinositol phosphate 5-phosphatase activity
- phosphatidylinositol-4-phosphate phosphatase activity
| | Cellular component | - dendrite
- clathrin-coated pit
- membrane
- clathrin-coated endocytic vesicle
- cytoplasm
- early endosome membrane
- endosome
- recycling endosome
- early endosome
- axon
- neuronal cell body
| | Biological process | - phosphatidylinositol catabolic process
- cardiac muscle hypertrophy in response to stress
- regulation of protein kinase B signaling
- phosphatidylinositol-mediated signaling
- clathrin-dependent endocytosis
- positive regulation of receptor recycling
- phosphatidylinositol dephosphorylation
- negative regulation of axon regeneration
- phosphatidylinositol biosynthetic process
- adult locomotory behavior
- regulation of endocytic recycling
- regulation of cell motility
- negative regulation of peptidyl-serine phosphorylation
- negative regulation of tyrosine phosphorylation of STAT protein
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001243194
NM_001243195
NM_014937 |
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| RefSeq (protein) | |
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NP_001230123
NP_001230124
NP_055752 |
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| Location (UCSC) | Chr 10: 119.73 – 119.83 Mb | Chr 7: 128.61 – 128.7 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.[5]
Function
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198825 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042105 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Inositol polyphosphate-5-phosphatase F". Retrieved 2018-05-14.
Further reading
- Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
- Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA (December 2009). "Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness". Circ. Res. 105 (12): 1240–7. doi:10.1161/CIRCRESAHA.109.208785. PMC 2802340. PMID 19875726.
- Kim HS, Li A, Ahn S, Song H, Zhang W (December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR...4E7330K. doi:10.1038/srep07330. PMC 4256660. PMID 25476455.
- Hsu F, Hu F, Mao Y (April 2015). "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling". J. Cell Biol. 209 (1): 97–110. doi:10.1083/jcb.201408027. PMC 4395482. PMID 25869669.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
