HYAL3

Protein-coding gene in the species Homo sapiens
HYAL3
Identifiers
AliasesHYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3
External IDsOMIM: 604038; MGI: 1330288; HomoloGene: 2626; GeneCards: HYAL3; OMA:HYAL3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for HYAL3
Genomic location for HYAL3
Band3p21.31Start50,292,831 bp[1]
End50,299,405 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for HYAL3
Genomic location for HYAL3
Band9 F1|9 58.19 cMStart107,458,017 bp[2]
End107,464,558 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • bone marrow

  • prefrontal cortex

  • left testis

  • right hemisphere of cerebellum

  • right testis

  • superior frontal gyrus

  • primary visual cortex

  • right frontal lobe
Top expressed in
  • embryo

  • embryo

  • right kidney

  • blastocyst

  • proximal tubule

  • spermatid

  • zygote

  • vestibular membrane of cochlear duct

  • ventricular zone

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hydrolase activity, acting on glycosyl bonds
  • protein binding
  • hyaluronoglucuronidase activity
  • hydrolase activity
  • catalytic activity
  • hyalurononglucosaminidase activity
Cellular component
  • extracellular region
  • acrosomal vesicle
  • acrosomal membrane
  • lysosome
  • endosome
  • early endosome
  • endoplasmic reticulum
  • plasma membrane
  • membrane
  • cytoplasmic vesicle
  • sperm midpiece
Biological process
  • cellular response to UV-B
  • cartilage development
  • response to antibiotic
  • cellular response to tumor necrosis factor
  • metabolism
  • cellular response to interleukin-1
  • inflammatory response
  • hyaluronan catabolic process
  • carbohydrate metabolic process
  • response to virus
  • ovarian follicle atresia
  • single fertilization
  • penetration of zona pellucida
  • negative regulation of ovarian follicle development
  • positive regulation of acrosomal vesicle exocytosis
  • viral entry into host cell
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8372

109685

Ensembl

ENSG00000186792

ENSMUSG00000036091

UniProt

O43820

Q8VEI3

RefSeq (mRNA)

NM_003549
NM_001200029
NM_001200030
NM_001200031
NM_001200032

NM_178020

RefSeq (protein)

NP_001186958
NP_001186959
NP_001186960
NP_001186961
NP_003540

NP_821139

Location (UCSC)Chr 3: 50.29 – 50.3 MbChr 9: 107.46 – 107.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.[5][6]

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186792 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036091 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.
  6. ^ a b "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".

Further reading

  • Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997. S2CID 4413586.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16. doi:10.3892/or.10.3.609 (inactive 31 January 2024). PMID 12684632.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lokeshwar VB, Schroeder GL, Carey RI, et al. (2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654–63. doi:10.1074/jbc.M203821200. PMID 12084718. S2CID 8385249.
  • Shuttleworth TL, Wilson MD, Wicklow BA, et al. (2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". J. Biol. Chem. 277 (25): 23008–18. doi:10.1074/jbc.M108991200. PMID 11929860. S2CID 24252110.
  • Triggs-Raine B, Salo TJ, Zhang H, et al. (1999). "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6296–300. Bibcode:1999PNAS...96.6296T. doi:10.1073/pnas.96.11.6296. PMC 26875. PMID 10339581.