Human leukocyte antigen serotype
HLA-A66 |
---|
(MHC Class I, A cell surface antigen) |
HLA-A66 |
About |
---|
Protein | transmembrane receptor/ligand |
---|
Structure | αβ heterodimer |
---|
Subunits | HLA-A*66--, β2-microglobulin |
---|
Older names | A10 |
---|
Subtypes |
---|
Subtype | allele | Available structures |
---|
A66.1 | *6601 | |
---|
A66.2 | *6602 | |
---|
{{{cNick3}}} | *66{{{cAllele3}}} | |
---|
{{{cNick4}}} | *66{{{cAllele4}}} | |
---|
|
Rare alleles |
---|
Subtype | allele | Available structures |
---|
A66.3 | *6603 | |
---|
{{{rnick2}}} | *66{{{rallele2}}} | |
---|
{{{rnick3}}} | *66{{{rallele3}}} | |
---|
|
Alleles link-out to IMGT/HLA database at EBI |
HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.
A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].
Serotype
A66 recognition of some HLA A*66 gene products[3] A*66 | A66 | A10 | A26 | A34 | Sample |
allele | % | % | % | % | size (N) |
*6601 | 20 | 10 | 61 | 8 | 799 |
*6602 | 38 | 10 | 4 | 27 | 205 |
*6603 | 32 | 7 | 7 | 18 | 28 |
A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.
A*6601 Frequencies
HLA A*6601 frequencies | | freq |
ref. | Population | (%) |
[4] | Cameroon Sawa | 7.7 |
[4] | Kenya Luo | 6.8 |
[4] | Cameroon Sawa | 7.7 |
[4] | Cameroon Bakola Pygmy | 5.8 |
[4] | Cameroon Baka Pygmy | 5.0 |
[4] | Kenya Nandi | 5.0 |
[4] | Zimbabwe Harare Shona | 0.2 |
[4] | Cameroon Baka Pygmy | 5.0 |
[4] | Cameroon Beti | 4.6 |
[4] | Cameroon Bamileke | 4.5 |
[4] | India West Bhils | 4.0 |
[4] | Zimbabwe Harere Shona | 3.8 |
[4] | Uganda Kampala | 3.8 |
[4] | India Mumbai Marathas | 2.5 |
[4] | Cape Verde Northwestern | 2.5 |
[4] | Czech republic | 2.4 |
[4] | Morocco Nador Metalsa | 2.1 |
[4] | Central Portugal | 2.0 |
[4] | India West Parsis | 2.0 |
[4] | South African Natal Zulu | 2.0 |
[4] | Kenya | 1.7 |
[4] | Tunisia Tunis | 1.7 |
[4] | Guinea Bissau | 1.5 |
[4] | Georgia Tbilisi | 1.4 |
[4] | Zambia Lusaka | 1.2 |
[4] | Italy Bergamo | 1.1 |
[4] | Pakistan Karachi Parsi | 1.1 |
[4] | Oman | 0.8 |
[4] | Sudanese | 0.8 |
[4] | Belgium | 0.5 |
[4] | Southeast France | 0.4 |
[4] | Mongolia Buriat | 0.4 |
[4] | Wales | 0.2 |
HLA A*6602 frequencies | | freq |
ref. | Population | (%) |
[4] | South African Natal Zulu | 1.5 |
[4] | Cameroon Yaounde | 1.1 |
[4] | Cameroon Bamileke | 0.6 |
[4] | Senegal Niokholo Mandenka | 0.5 |
[4] | Kenya Nandi | 0.4 |
[4] | Zimbabwe Harare Shona | 0.2 |
[4] | Wales | 0.03 |
HLA A*6603 frequencies |
| | freq |
ref. | Population | (%) |
[4] | Cameroon Pygmy Baka | 10.0 |
[4] | Cameroon Bakola Pygmy | 9.0 |
[4] | Cameroon Sawa | 7.7 |
[4] | CAR Mbenzele Pygmy | 2.8 |
[4] | Zimbabwe Harare Shona | 0.2 |
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.