HIP2

Protein-coding gene in the species Homo sapiens
UBE2K
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1YLA, 2O25, 3E46, 3F92, 3K9O, 3K9P, 5DFL

Identifiers
AliasesUBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
External IDsOMIM: 602846; MGI: 1858216; HomoloGene: 3903; GeneCards: UBE2K; OMA:UBE2K - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for UBE2K
Genomic location for UBE2K
Band4p14Start39,698,109 bp[1]
End39,782,792 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for UBE2K
Genomic location for UBE2K
Band5 C3.1|5 33.72 cMStart65,694,576 bp[2]
End65,756,331 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • secondary oocyte

  • islet of Langerhans

  • postcentral gyrus

  • Brodmann area 23

  • middle temporal gyrus

  • amniotic fluid

  • buccal mucosa cell

  • superior frontal gyrus

  • stromal cell of endometrium
Top expressed in
  • seminiferous tubule

  • zygote

  • tail of embryo

  • primary oocyte

  • primitive streak

  • secondary oocyte

  • abdominal wall

  • genital tubercle

  • yolk sac

  • hair follicle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • transferase activity
  • nucleotide binding
  • ubiquitin-ubiquitin ligase activity
  • protein binding
  • ATP binding
  • ubiquitin protein ligase binding
  • ubiquitin conjugating enzyme activity
Cellular component
  • cytoplasm
  • filopodium tip
  • nucleus
  • cytosol
Biological process
  • protein K48-linked ubiquitination
  • positive regulation of type I interferon-mediated signaling pathway
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  • free ubiquitin chain polymerization
  • positive regulation of peptidyl-threonine phosphorylation
  • ubiquitin-dependent protein catabolic process
  • cellular response to interferon-beta
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • regulation of proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3093

53323

Ensembl

ENSG00000078140

ENSMUSG00000029203

UniProt

P61086

P61087

RefSeq (mRNA)
NM_005339
NM_001111112
NM_001111113
NM_001312646
NM_001312647

NM_001312648
NM_032733

NM_016786
NM_001310618
NM_001310619

RefSeq (protein)
NP_001104582
NP_001104583
NP_001299575
NP_001299576
NP_001299577

NP_005330

NP_001297547
NP_001297548
NP_058066

Location (UCSC)Chr 4: 39.7 – 39.78 MbChr 5: 65.69 – 65.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.[5][6][7]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.[7]

Interactions

HIP2 has been shown to interact with Huntingtin[5][8] and RNF2.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078140 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029203 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625.
  6. ^ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885. S2CID 32160828.
  7. ^ a b "Entrez Gene: HIP2 huntingtin interacting protein 2".
  8. ^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
  9. ^ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. S2CID 42977319.

Further reading

  • Petersén A, Mani K, Brundin P (1999). "Recent advances on the pathogenesis of Huntington's disease". Exp. Neurol. 157 (1): 1–18. doi:10.1006/exnr.1998.7006. PMID 10222105. S2CID 12974652.
  • Coux O, Goldberg AL (1998). "Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1". J. Biol. Chem. 273 (15): 8820–8. doi:10.1074/jbc.273.15.8820. PMID 9535861.
  • Whitby FG, Xia G, Pickart CM, Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes". J. Biol. Chem. 273 (52): 34983–91. doi:10.1074/jbc.273.52.34983. PMID 9857030.
  • Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I (2000). "Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis". Arterioscler. Thromb. Vasc. Biol. 20 (1): 128–34. doi:10.1161/01.ATV.20.1.128. PMID 10634809.
  • Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I (2000). "Regulation of macrophage-specific gene expression by degenerated lipoproteins". Electrophoresis. 21 (2): 338–46. doi:10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9. PMID 10675012. S2CID 22857626.
  • Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. S2CID 42977319.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. Bibcode:2006PNAS..10311589F. doi:10.1073/pnas.0605215103. PMC 1520313. PMID 16868077.
  • de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". Mol. Cell. Neurosci. 34 (1): 10–9. doi:10.1016/j.mcn.2006.09.006. PMID 17092742. S2CID 9704303.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
  • t
  • e
  • 1yla: Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2)
    1yla: Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2)
  • 2bep: CRYSTAL STRUCTURE OF UBIQUITIN CONJUGATING ENZYME E2-25K
    2bep: CRYSTAL STRUCTURE OF UBIQUITIN CONJUGATING ENZYME E2-25K
  • 2bf8: CRYSTAL STRUCTURE OF SUMO MODIFIED UBIQUITIN CONJUGATING ENZYME E2-25K
    2bf8: CRYSTAL STRUCTURE OF SUMO MODIFIED UBIQUITIN CONJUGATING ENZYME E2-25K
  • 2o25: Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9
    2o25: Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9


Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e