HECW2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | HECW2, NEDL2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, NDHSAL |
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External IDs | OMIM: 617245; MGI: 2685817; HomoloGene: 66192; GeneCards: HECW2; OMA:HECW2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q32.3 | Start | 196,189,099 bp[1] |
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End | 196,593,684 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 C1.1 | Start | 53,846,035 bp[2] |
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End | 54,234,327 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - myocardium of left ventricle
- Brodmann area 23
- middle temporal gyrus
- visceral pleura
- testicle
- upper lobe of lung
- upper lobe of left lung
- right lung
- primary visual cortex
- Brodmann area 46
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| Top expressed in | - epithelium of stomach
- lumbar subsegment of spinal cord
- substantia nigra
- medial geniculate nucleus
- lateral geniculate nucleus
- primary motor cortex
- habenula
- medial dorsal nucleus
- prefrontal cortex
- lobe of cerebellum
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transferase activity
- ubiquitin-protein transferase activity
- protein binding
- ubiquitin protein ligase activity
| Cellular component | - mitotic spindle
- spindle
- cytoskeleton
- cytoplasm
| Biological process | - protein ubiquitination
- regulation of mitotic metaphase/anaphase transition
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
- positive regulation of protein catabolic process
- regulation of dendrite morphogenesis
- negative regulation of sodium ion transmembrane transporter activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001304840 NM_020760 NM_001348768 |
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RefSeq (protein) | |
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NP_001291769 NP_065811 NP_001335697 |
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Location (UCSC) | Chr 2: 196.19 – 196.59 Mb | Chr 1: 53.85 – 54.23 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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