HCLS1

Protein-coding gene in the species Homo sapiens

HCLS1

Identifiers

Aliases

HCLS1, CTTNL, HS1, lckBP1, p75, hematopoietic cell-specific Lyn substrate 1

External IDs

OMIM: 601306; MGI: 104568; HomoloGene: 38034; GeneCards: HCLS1; OMA:HCLS1 - orthologs

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[1]

Band	16\|16 B3	Start	36,755,345 bp^[1]
Band	16\|16 B3	End	36,783,574 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

blood

spleen

appendix

bone marrow cells

lymph node

right lung

trabecular bone

upper lobe of left lung

gallbladder

Top expressed in

granulocyte

mesenteric lymph nodes

thymus

spleen

neural layer of retina

bone marrow

stroma of bone marrow

ankle joint

tibiofemoral joint

blood

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	SH3 domain binding protein binding actin binding protein kinase binding protein-containing complex binding
Cellular component	cytoplasm membrane transcription regulator complex mitochondrion nucleus cytosol plasma membrane
Biological process	positive regulation of protein kinase B signaling intracellular signal transduction regulation of transcription, DNA-templated positive regulation of tyrosine phosphorylation of STAT protein positive regulation of macrophage differentiation negative regulation of transcription by RNA polymerase II cellular response to cytokine stimulus positive regulation of peptidyl-serine phosphorylation regulation of actin filament polymerization actin filament polymerization positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of granulocyte differentiation erythrocyte differentiation negative regulation of leukocyte apoptotic process response to hormone positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of actin cytoskeleton reorganization positive regulation of transcription by RNA polymerase II positive regulation of protein import into nucleus positive regulation of DNA-binding transcription factor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3059


15163

Ensembl


n/a


ENSMUSG00000022831

UniProt


P14317


P49710

RefSeq (mRNA)


NM_005335 NM_001292041


NM_008225

RefSeq (protein)


NP_001278970 NP_005326


NP_032251

Location (UCSC)

n/a

Chr 16: 36.76 – 36.78 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.^[4]^[5]^[6]

Interactions

HCLS1 has been shown to interact with Caspase 3.^[7]^[8]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022831 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID 8978766.
^ van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
^ "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
^ Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1). England: 41–7. doi:10.1042/bj3640041. ISSN 0264-6021. PMC 1222543. PMID 11988074.
^ Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4). United States: 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Kitamura D, Kaneko H, Miyagoe Y, et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage". Nucleic Acids Res. 17 (22): 9367–79. PMC 335138. PMID 2587259.
Yamanashi Y, Okada M, Semba T, et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631–5. Bibcode:1993PNAS...90.3631Y. doi:10.1073/pnas.90.8.3631. PMC 46355. PMID 7682714.
Hata D, Nakamura T, Kawakami T, et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking". Immunol. Lett. 40 (1): 65–71. doi:10.1016/0165-2478(94)90208-9. PMID 7927516.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. doi:10.4049/jimmunol.158.6.2736. PMID 9058808. S2CID 25584050.
Yamanashi Y, Fukuda T, Nishizumi H, et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis". J. Exp. Med. 185 (7): 1387–92. doi:10.1084/jem.185.7.1387. PMC 2196252. PMID 9104825.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase". J. Biol. Chem. 274 (11): 7557–64. doi:10.1074/jbc.274.11.7557. PMID 10066823.
Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin". Blood. 93 (10): 3347–54. doi:10.1182/blood.V93.10.3347.410k06_3347_3354. PMID 10233887.
Takemoto Y, Furuta M, Sato M, et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3". Int. Immunol. 11 (12): 1957–64. doi:10.1093/intimm/11.12.1957. PMID 10590261.
Ruzzene M, Brunati AM, Sarno S, et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2". Eur. J. Biochem. 267 (10): 3065–72. doi:10.1046/j.1432-1033.2000.01333.x. PMID 10806407.
Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. PMC 1222543. PMID 11988074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
Uruno T, Zhang P, Liu J, et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization". Biochem. J. 371 (Pt 2): 485–93. doi:10.1042/BJ20021791. PMC 1223309. PMID 12534372.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.