GTPBP4

Protein-coding gene in the species Homo sapiens
GTPBP4
Identifiers
AliasesGTPBP4, CRFG, NGB, NOG1, GTP binding protein 4
External IDsMGI: 1916487; HomoloGene: 7100; GeneCards: GTPBP4; OMA:GTPBP4 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GTPBP4
Genomic location for GTPBP4
Band10p15.3Start988,434 bp[1]
End1,019,932 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GTPBP4
Genomic location for GTPBP4
Band13|13 A1Start9,016,367 bp[2]
End9,046,119 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • epithelium of nasopharynx

  • Achilles tendon

  • mucosa of urinary bladder

  • amniotic fluid

  • cartilage tissue

  • stromal cell of endometrium

  • Skeletal muscle tissue of rectus abdominis

  • right adrenal cortex

  • gastrocnemius muscle
Top expressed in
  • otic placode

  • saccule

  • otic vesicle

  • morula

  • morula

  • epiblast

  • embryo

  • blastocyst

  • Ileal epithelium

  • primitive streak
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
  • RNA binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • nuclear membrane
  • membrane
  • nucleolus
  • perinuclear region of cytoplasm
  • nucleus
  • cytosol
Biological process
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • ribosome biogenesis
  • negative regulation of cell-cell adhesion
  • protein stabilization
  • negative regulation of DNA replication
  • negative regulation of protein ubiquitination
  • negative regulation of cell migration
  • osteoblast differentiation
  • negative regulation of collagen binding
  • negative regulation of cell population proliferation
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23560

69237

Ensembl

ENSG00000107937

ENSMUSG00000021149

UniProt

Q9BZE4

Q99ME9

RefSeq (mRNA)

NM_012341

NM_027000

RefSeq (protein)

NP_036473

NP_081276

Location (UCSC)Chr 10: 0.99 – 1.02 MbChr 13: 9.02 – 9.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.[5][6]

GTPases function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G protein-coupled receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107937 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021149 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Laping NJ, Olson BA, Zhu Y (Apr 2001). "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease". J Am Soc Nephrol. 12 (5): 883–90. doi:10.1681/ASN.V125883. PMID 11316846.
  6. ^ a b "Entrez Gene: GTPBP4 GTP binding protein 4".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Lee H, Kim D, Dan HC, et al. (2007). "Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein". Mol. Cell. Biol. 27 (6): 2103–19. doi:10.1128/MCB.00572-06. PMC 1820506. PMID 17210637.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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