GTF3C5

Protein-coding gene in the species Homo sapiens
GTF3C5
Identifiers
AliasesGTF3C5, TFIIIC63, TFIIICepsilon, TFiiiC2-63, general transcription factor IIIC subunit 5
External IDsOMIM: 604890; MGI: 1917489; HomoloGene: 40806; GeneCards: GTF3C5; OMA:GTF3C5 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GTF3C5
Genomic location for GTF3C5
Band9q34.13Start133,030,675 bp[1]
End133,058,503 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GTF3C5
Genomic location for GTF3C5
Band2|2 A3Start28,456,323 bp[2]
End28,473,763 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right uterine tube

  • left ovary

  • apex of heart

  • anterior pituitary

  • right ovary

  • body of uterus

  • canal of the cervix

  • tibial nerve

  • ectocervix
Top expressed in
  • ventricular zone

  • tail of embryo

  • neural layer of retina

  • genital tubercle

  • epiblast

  • yolk sac

  • neural tube

  • internal carotid artery

  • external carotid artery

  • fetal liver hematopoietic progenitor cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA polymerase III type 1 promoter sequence-specific DNA binding
  • RNA polymerase III type 2 promoter sequence-specific DNA binding
  • RNA polymerase III general transcription initiation factor activity
Cellular component
  • transcription factor TFIIIC complex
  • nucleus
  • nucleoplasm
Biological process
  • skeletal muscle cell differentiation
  • tRNA transcription by RNA polymerase III
  • 5S class rRNA transcription by RNA polymerase III
  • transcription, DNA-templated
  • transcription by RNA polymerase III
  • RNA polymerase III preinitiation complex assembly
  • transcription initiation from RNA polymerase III promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9328

70239

Ensembl

ENSG00000148308

ENSMUSG00000026816

UniProt

Q9Y5Q8

Q8R2T8

RefSeq (mRNA)

NM_001122823
NM_001286709
NM_012087

NM_001290484
NM_148928

RefSeq (protein)

NP_001116295
NP_001273638
NP_036219

NP_001277413
NP_683730

Location (UCSC)Chr 9: 133.03 – 133.06 MbChr 2: 28.46 – 28.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.[5][6]

Interactions

GTF3C5 has been shown to interact with GTF3C2[5] and GTF3C4.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148308 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026816 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  6. ^ "Entrez Gene: GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa".
  7. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  • Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.


  • v
  • t
  • e