FMNL3

Protein-coding gene in humans

FMNL3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4EAH

Identifiers

Aliases

FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3

External IDs

OMIM: 616288; MGI: 109569; HomoloGene: 69101; GeneCards: FMNL3; OMA:FMNL3 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.12	Start	49,636,499 bp^[1]
Band	12q13.12	End	49,708,165 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F1	Start	99,215,106 bp^[2]
Band	15\|15 F1	End	99,268,363 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

appendix

right coronary artery

stromal cell of endometrium

lymph node

Achilles tendon

apex of heart

granulocyte

left coronary artery

right lung

Top expressed in

primary oocyte

granulocyte

calvaria

internal carotid artery

external carotid artery

secondary oocyte

zygote

endocardial cushion

semi-lunar valve

ankle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	GTPase activating protein binding actin binding
Cellular component	cytoplasm membrane Golgi apparatus cytosol plasma membrane intracellular membrane-bounded organelle
Biological process	multicellular organism development actin cytoskeleton organization angiogenesis cellular component organization cytoskeleton organization regulation of cell shape cell migration cortical actin cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


91010


22379

Ensembl


ENSG00000161791


ENSMUSG00000023008

UniProt


Q8IVF7


Q6ZPF4

RefSeq (mRNA)


NM_175736 NM_198900 NM_001367835


NM_011711 NM_001310622 NM_001310623

RefSeq (protein)


NP_783863 NP_944489 NP_001354764


NP_001297551 NP_001297552 NP_035841

Location (UCSC)

Chr 12: 49.64 – 49.71 Mb

Chr 15: 99.22 – 99.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.^[5]^[6]

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.^[5] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.^[7] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161791 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: formin-like 3".
^ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
^ Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
^ Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.