Protein-coding gene in the species Homo sapiens
FBXO24 |
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Identifiers |
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Aliases | FBXO24, FBX24, F-box protein 24 |
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External IDs | OMIM: 609097; MGI: 1918426; HomoloGene: 14131; GeneCards: FBXO24; OMA:FBXO24 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7q22.1 | Start | 100,583,982 bp[1] |
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End | 100,601,117 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 G2 | Start | 137,610,765 bp[2] |
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End | 137,627,264 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - left testis
- right testis
- sperm
- gonad
- testicle
- sural nerve
- granulocyte
- stromal cell of endometrium
- right uterine tube
- ectocervix
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| Top expressed in | - spermatid
- seminiferous tubule
- granulocyte
- spermatocyte
- embryo
- embryo
- neural layer of retina
- esophagus
- jejunum
- ventricular zone
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - ubiquitin-protein transferase activity
- protein binding
| Cellular component | | Biological process | | Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001163499 NM_012172 NM_033506 |
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RefSeq (protein) | |
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NP_001156971 NP_036304 NP_277041 |
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Location (UCSC) | Chr 7: 100.58 – 100.6 Mb | Chr 5: 137.61 – 137.63 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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F-box only protein 24 is a protein that in humans is encoded by the FBXO24 gene.[5][6][7]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates two transcript variants.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106336 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089984 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
- ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
- ^ a b "Entrez Gene: FBXO24 F-box protein 24".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.