Extended synaptotagmin-1

Protein-coding gene in the species Homo sapiens
ESYT1
Identifiers
AliasesESYT1, FAM62A, MBC2, extended synaptotagmin protein 1, extended synaptotagmin 1
External IDsOMIM: 616670; MGI: 1344426; HomoloGene: 40794; GeneCards: ESYT1; OMA:ESYT1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ESYT1
Genomic location for ESYT1
Band12q13.2Start56,118,250 bp[1]
End56,144,674 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ESYT1
Genomic location for ESYT1
Band10|10 D3Start128,345,834 bp[2]
End128,361,740 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • abdominal fat

  • granulocyte

  • right uterine tube

  • gastric mucosa

  • body of uterus

  • subcutaneous adipose tissue

  • right coronary artery

  • Descending thoracic aorta

  • popliteal artery

  • tibial arteries
Top expressed in
  • granulocyte

  • lip

  • esophagus

  • muscle of thigh

  • zygote

  • ascending aorta

  • thymus

  • pharynx

  • tail of embryo

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • lipid binding
  • identical protein binding
  • calcium ion binding
  • calcium-dependent phospholipid binding
  • phosphatidylethanolamine binding
  • phosphatidylcholine binding
  • phosphatidylinositol binding
Cellular component
  • organelle membrane contact site
  • integral component of membrane
  • integral component of endoplasmic reticulum membrane
  • plasma membrane
  • membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • intracellular membrane-bounded organelle
  • intrinsic component of endoplasmic reticulum membrane
  • extrinsic component of cytoplasmic side of plasma membrane
Biological process
  • lipid transport
  • glycosphingolipid metabolic process
  • transport
  • endoplasmic reticulum-plasma membrane tethering
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23344

23943

Ensembl

ENSG00000139641

ENSMUSG00000025366

UniProt

Q9BSJ8

Q3U7R1

RefSeq (mRNA)

NM_015292
NM_001184796

NM_011843

RefSeq (protein)

NP_001171725
NP_056107

NP_035973

Location (UCSC)Chr 12: 56.12 – 56.14 MbChr 10: 128.35 – 128.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Extended synaptotagmin-1 is a protein in humans that is encoded by the ESYT1 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139641 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Morris NJ, Ross SA, Neveu JM, Lane WS, Lienhard GE (Jul 1999). "Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains". Biochim Biophys Acta. 1431 (2): 525–30. doi:10.1016/S0167-4838(99)00068-0. PMID 10350628.
  7. ^ Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
  8. ^ "Entrez Gene: FAM62A family with sequence similarity 62 (C2 domain containing), member A".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.


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