Exosome component 4

Protein-coding gene in the species Homo sapiens

EXOSC4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2NN6

Identifiers
AliasesEXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A, Exosome component 4
External IDsOMIM: 606491; MGI: 1923576; HomoloGene: 6017; GeneCards: EXOSC4; OMA:EXOSC4 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for EXOSC4
Genomic location for EXOSC4
Band8q24.3Start144,078,648 bp[1]
End144,080,648 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for EXOSC4
Genomic location for EXOSC4
Band15|15 D3Start76,211,597 bp[2]
End76,214,877 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • mucosa of transverse colon

  • apex of heart

  • right adrenal gland

  • left adrenal gland

  • right adrenal cortex

  • left adrenal cortex

  • right lobe of liver

  • gonad
Top expressed in
  • embryo

  • right kidney

  • otic placode

  • yolk sac

  • embryo

  • proximal tubule

  • otic vesicle

  • medial ganglionic eminence

  • facial motor nucleus

  • ankle joint
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • exoribonuclease activity
  • 3'-5'-exoribonuclease activity
  • RNA binding
  • mRNA 3'-UTR AU-rich region binding
Cellular component
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • cytoplasm
  • exosome (RNase complex)
  • nucleolus
  • nucleus
  • nucleoplasm
  • cytosol
  • intermediate filament cytoskeleton
Biological process
  • defense response to virus
  • rRNA 3'-end processing
  • rRNA catabolic process
  • polyadenylation-dependent snoRNA 3'-end processing
  • U4 snRNA 3'-end processing
  • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
  • positive regulation of cell growth
  • nuclear-transcribed mRNA catabolic process
  • DNA deamination
  • maturation of 5.8S rRNA
  • regulation of mRNA stability
  • nuclear mRNA surveillance
  • exonucleolytic catabolism of deadenylated mRNA
  • histone mRNA catabolic process
  • rRNA processing
  • RNA phosphodiester bond hydrolysis, exonucleolytic
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54512

109075

Ensembl

ENSG00000178896

ENSMUSG00000034259

UniProt

Q9NPD3

Q921I9

RefSeq (mRNA)

NM_019037

NM_175399

RefSeq (protein)

NP_061910

NP_780608

Location (UCSC)Chr 8: 144.08 – 144.08 MbChr 15: 76.21 – 76.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.[5]

Interactions

Exosome component 4 has been shown to interact with Exosome component 2.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178896 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034259 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EXOSC4 exosome component 4".
  6. ^ Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.

Further reading

  • Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
  • Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
  • Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl:2066/261980. PMID 11812149.
  • Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
  • Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus". J. Biol. Chem. 278 (33): 30698–704. doi:10.1074/jbc.M302488200. hdl:2066/186428. PMID 12788944.
  • Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways". RNA. 13 (7): 1027–35. doi:10.1261/rna.575107. PMC 1894934. PMID 17545563.
  • v
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  • 2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
    2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40


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