EAF1

Protein-coding gene in the species Homo sapiens
EAF1
Identifiers
AliasesEAF1, ELL associated factor 1
External IDsOMIM: 608315; MGI: 1921677; HomoloGene: 12561; GeneCards: EAF1; OMA:EAF1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for EAF1
Genomic location for EAF1
Band3p25.1Start15,427,598 bp[1]
End15,450,635 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for EAF1
Genomic location for EAF1
Band14|14 BStart31,216,356 bp[2]
End31,231,815 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amniotic fluid

  • islet of Langerhans

  • decidua

  • monocyte

  • secondary oocyte

  • lower lobe of lung

  • palpebral conjunctiva

  • pancreatic epithelial cell

  • epithelium of nasopharynx

  • prefrontal cortex
Top expressed in
  • epithelium of lens

  • tail of embryo

  • olfactory epithelium

  • decidua

  • primitive streak

  • superior cervical ganglion

  • gastrula

  • thymus

  • genital tubercle

  • endothelial cell of lymphatic vessel
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Cajal body
  • nuclear speck
  • transcription elongation factor complex
  • super elongation complex
  • intracellular membrane-bounded organelle
  • intercellular bridge
  • nucleus
  • nucleoplasm
  • nuclear body
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85403

74427

Ensembl

ENSG00000144597

ENSMUSG00000021890

UniProt

Q96JC9

Q9D4C5

RefSeq (mRNA)

NM_033083

NM_028932

RefSeq (protein)

NP_149074

NP_083208

Location (UCSC)Chr 3: 15.43 – 15.45 MbChr 14: 31.22 – 31.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene.[5][6] It is part of the EAF family of proteins.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144597 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021890 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. doi:10.1182/blood.V98.1.201. PMID 11418481. S2CID 2577367.
  6. ^ "Entrez Gene: EAF1 ELL associated factor 1".

Further reading

  • Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. doi:10.1091/mbc.E02-07-0394. PMC 153119. PMID 12686606.
  • Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. Bibcode:2005PNAS..10210094K. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
  • Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.
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