DLL1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1, NEDBAS |
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External IDs | OMIM: 606582; MGI: 104659; HomoloGene: 4104; GeneCards: DLL1; OMA:DLL1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6q27 | Start | 170,282,206 bp[1] |
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End | 170,306,565 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17 A2|17 8.95 cM | Start | 15,587,616 bp[2] |
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End | 15,597,134 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - spleen
- ventricular zone
- skin of abdomen
- skin of leg
- prostate
- apex of heart
- mucosa of esophagus
- vagina
- right auricle
- minor salivary glands
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| Top expressed in | - paraxial mesoderm
- tail of embryo
- ventricular zone
- primitive streak
- ciliary body
- tongue muscle
- corneal stroma
- ganglionic eminence
- medial ganglionic eminence
- right lung
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - calcium ion binding
- scaffold protein binding
- Tat protein binding
- Notch binding
- protein binding
| Cellular component | - integral component of membrane
- membrane
- adherens junction
- plasma membrane
- integral component of plasma membrane
- extracellular region
- cell junction
- apical plasma membrane
- membrane raft
- cytoplasmic vesicle
| Biological process | - Notch signaling pathway
- somitogenesis
- negative regulation of interleukin-10 production
- proximal/distal pattern formation
- cell differentiation
- negative regulation of myoblast differentiation
- organ growth
- regulation of somitogenesis
- regulation of cell division
- negative regulation of neuron differentiation
- loop of Henle development
- negative regulation of inner ear auditory receptor cell differentiation
- astrocyte development
- somite specification
- negative regulation of glial cell apoptotic process
- negative regulation of cell differentiation
- neuron fate specification
- endothelial tip cell fate specification
- cell-cell signaling
- regulation of skeletal muscle tissue growth
- marginal zone B cell differentiation
- skeletal muscle tissue growth
- lateral inhibition
- regulation of vascular endothelial growth factor signaling pathway
- neuronal stem cell population maintenance
- positive regulation of sprouting angiogenesis
- regulation of blood pressure
- heart looping
- cerebellar molecular layer formation
- cell communication
- positive regulation of endocytosis
- retina morphogenesis in camera-type eye
- proximal tubule development
- negative regulation of epidermal cell differentiation
- clathrin-dependent endocytosis
- determination of left/right symmetry
- regulation of cell adhesion
- cerebellar Purkinje cell layer structural organization
- compartment pattern specification
- positive regulation of gene expression
- retina development in camera-type eye
- skin epidermis development
- positive regulation of cell population proliferation
- nephron development
- spinal cord development
- cell fate determination
- inner ear development
- multicellular organism development
- regulation of growth
- Notch signaling pathway involved in arterial endothelial cell fate commitment
- type B pancreatic cell development
- negative regulation of epithelial cell differentiation
- negative regulation of myeloid cell differentiation
- positive regulation of skeletal muscle tissue growth
- regulation of neurogenesis
- left/right axis specification
- positive regulation of Notch signaling pathway
- negative regulation of cell population proliferation
- positive regulation of transcription by RNA polymerase II
- negative regulation of cardiac muscle cell differentiation
- hemopoiesis
- energy homeostasis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000275555 ENSG00000198719 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 170.28 – 170.31 Mb | Chr 17: 15.59 – 15.6 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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