DPF2

Protein-coding gene in the species Homo sapiens
DPF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3IUF

Identifiers
AliasesDPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDsOMIM: 601671; MGI: 109529; HomoloGene: 21265; GeneCards: DPF2; OMA:DPF2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for DPF2
Genomic location for DPF2
Band11q13.1Start65,333,852 bp[1]
End65,354,262 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for DPF2
Genomic location for DPF2
Band19 A|19 4.34 cMStart5,946,544 bp[2]
End5,963,038 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • Achilles tendon

  • ventricular zone

  • body of uterus

  • right ovary

  • left ovary

  • ganglionic eminence

  • canal of the cervix

  • muscle layer of sigmoid colon
Top expressed in
  • tail of embryo

  • genital tubercle

  • neural layer of retina

  • ventricular zone

  • otic vesicle

  • internal carotid artery

  • external carotid artery

  • primitive streak

  • epiblast

  • lens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • protein binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription corepressor activity
  • histone acetyltransferase activity
  • histone binding
  • H3K9me3 modified histone binding
  • lysine-acetylated histone binding
Cellular component
  • nucleus
  • nucleoplasm
  • intracellular membrane-bounded organelle
  • centrosome
  • cytoplasm
  • cytosol
  • histone acetyltransferase complex
  • nBAF complex
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • apoptotic signaling pathway
  • apoptotic process
  • negative regulation of transcription by RNA polymerase II
  • chromatin organization
  • nervous system development
  • histone acetylation
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of myeloid progenitor cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5977

19708

Ensembl

ENSG00000133884

ENSMUSG00000024826

UniProt

Q92785

Q61103

RefSeq (mRNA)

NM_006268
NM_001330308

NM_001291078
NM_011262

RefSeq (protein)

NP_001317237
NP_006259
NP_006259.1

NP_001278007
NP_035392

Location (UCSC)Chr 11: 65.33 – 65.35 MbChr 19: 5.95 – 5.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[5][6]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133884 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024826 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
  6. ^ a b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

Further reading

  • Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. doi:10.1016/S0021-9258(18)43910-5. PMID 7961935.
  • Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
  • Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
  • Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388. S2CID 22559464.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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