DENND1A

Protein-coding gene in the species Homo sapiens
DENND1A
Identifiers
AliasesDENND1A, FAM31A, KIAA1608, DENN domain containing 1A
External IDsOMIM: 613633; MGI: 2442794; HomoloGene: 17141; GeneCards: DENND1A; OMA:DENND1A - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for DENND1A
Genomic location for DENND1A
Band9q33.3Start123,379,654 bp[1]
End123,930,152 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DENND1A
Genomic location for DENND1A
Band2|2 BStart37,689,003 bp[2]
End38,177,402 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • bone marrow cells

  • ventricular zone

  • mucosa of ileum

  • granulocyte

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • prefrontal cortex

  • blood
Top expressed in
  • neural layer of retina

  • zygote

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • secondary oocyte

  • muscle of thigh

  • right kidney

  • spermatocyte

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • guanyl-nucleotide exchange factor activity
  • SH3 domain binding
  • lipid binding
  • phosphatidylinositol phosphate binding
  • phosphatidylinositol-3-phosphate binding
Cellular component
  • membrane
  • plasma membrane
  • synapse
  • cell junction
  • neuronal cell body
  • dendrite
  • clathrin-coated vesicle membrane
  • presynaptic membrane
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • nucleoplasm
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • endocytosis
  • regulation of Rab protein signal transduction
  • synaptic vesicle endocytosis
  • protein transport
  • positive regulation of GTPase activity
  • endocytic recycling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57706

227801

Ensembl

ENSG00000119522

ENSMUSG00000035392

UniProt

Q8TEH3

Q8K382

RefSeq (mRNA)
NM_020946
NM_024820
NM_001352964
NM_001352965
NM_001352966

NM_001352967
NM_001352968
NM_001393654
NM_001400446
NM_001400449

NM_146122
NM_001362973
NM_001362977
NM_001362978

RefSeq (protein)
NP_065997
NP_079096
NP_001339893
NP_001339894
NP_001339895

NP_001339896
NP_001339897

NP_666234
NP_001349902
NP_001349906
NP_001349907

Location (UCSC)Chr 9: 123.38 – 123.93 MbChr 2: 37.69 – 38.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DENN domain-containing protein 1A is a protein that in humans is encoded by the DENND1A gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119522 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035392 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  6. ^ "Entrez Gene: DENND1A DENN/MADD domain containing 1A".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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