Protein-coding gene in the species Homo sapiens
| DCTN3 |
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| Identifiers |
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| Aliases | DCTN3, DCTN-22, DCTN22, dynactin subunit 3 |
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| External IDs | OMIM: 607387; MGI: 1859251; HomoloGene: 5233; GeneCards: DCTN3; OMA:DCTN3 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 9 (human)[1] |
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| | Band | 9p13.3 | Start | 34,613,545 bp[1] |
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| End | 34,620,523 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4|4 A5 | Start | 41,714,798 bp[2] |
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| End | 41,723,170 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - ganglionic eminence
- prefrontal cortex
- ventricular zone
- right frontal lobe
- anterior pituitary
- right hemisphere of cerebellum
- Brodmann area 9
- nucleus accumbens
- muscle of thigh
- skin of leg
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| | Top expressed in | - saccule
- medial ganglionic eminence
- otic vesicle
- otic placode
- superior frontal gyrus
- facial motor nucleus
- right kidney
- primary visual cortex
- motor neuron
- choroid plexus of fourth ventricle
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - structural molecule activity
- protein binding
| | Cellular component | - cytoplasm
- centrosome
- dynactin complex
- spindle
- chromosome
- microtubule organizing center
- microtubule associated complex
- midbody
- perinuclear region of cytoplasm
- cleavage furrow
- chromosome, centromeric region
- cytoskeleton
- kinetochore
- nucleolus
- cytosol
- microtubule
| | Biological process | - antigen processing and presentation of exogenous peptide antigen via MHC class II
- cell division
- endoplasmic reticulum to Golgi vesicle-mediated transport
- G2/M transition of mitotic cell cycle
- microtubule-based process
- cell cycle
- ciliary basal body-plasma membrane docking
- mitotic cell cycle
- regulation of G2/M transition of mitotic cell cycle
- cytoskeleton-dependent cytokinesis
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_024348
NM_001281425
NM_001281426
NM_001281427
NM_007234 |
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| RefSeq (protein) | |
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NP_001268354
NP_001268355
NP_001268356
NP_009165
NP_077324 |
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| Location (UCSC) | Chr 9: 34.61 – 34.62 Mb | Chr 4: 41.71 – 41.72 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.[5][6][7]
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000137100 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028447 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Karki S, LaMonte B, Holzbaur EL (Sep 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". J Cell Biol. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC 2132867. PMID 9722614.
- ^ Mills DR, Jackson CL (Apr 2001). "Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 166. doi:10.1159/000056892. PMID 11306820. S2CID 84893310.
- ^ a b "Entrez Gene: DCTN3 dynactin 3 (p22)".
Further reading
- Karki S, Tokito MK, Holzbaur EL (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". J. Biol. Chem. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
