CRIPT

Protein-coding gene in the species Homo sapiens
CRIPT
Identifiers
AliasesCRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain
External IDsOMIM: 604594; MGI: 1929655; HomoloGene: 8572; GeneCards: CRIPT; OMA:CRIPT - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CRIPT
Genomic location for CRIPT
Band2p21Start46,616,416 bp[1]
End46,630,176 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CRIPT
Genomic location for CRIPT
Band17|17 E4Start87,332,978 bp[2]
End87,343,238 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • corpus epididymis

  • caput epididymis

  • tail of epididymis

  • cerebellar vermis

  • internal globus pallidus

  • superficial temporal artery

  • visceral pleura

  • buccal mucosa cell

  • trabecular bone
Top expressed in
  • zygote

  • spermatocyte

  • spermatid

  • medial ganglionic eminence

  • endocardial cushion

  • Epithelium of choroid plexus

  • seminal vesicula

  • blood

  • facial motor nucleus

  • anterior horn of spinal cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • scaffold protein binding
  • PDZ domain binding
  • protein binding
  • protein-containing complex binding
Cellular component
  • cytoplasm
  • dendritic shaft
  • cell junction
  • neuronal cell body
  • dendritic spine
  • dendrite
  • cell projection
  • synapse
  • nucleolus
  • postsynaptic density
  • nucleus
  • fibrillar center
Biological process
  • regulation of postsynaptic density protein 95 clustering
  • protein localization to microtubule
  • cytoplasmic microtubule organization
  • establishment of protein localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9419

56724

Ensembl

ENSG00000119878

ENSMUSG00000024146

UniProt

Q9P021

O70333

RefSeq (mRNA)

NM_014171

NM_019936

RefSeq (protein)

NP_054890

NP_064320

Location (UCSC)Chr 2: 46.62 – 46.63 MbChr 17: 87.33 – 87.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.[5][6][7][8][9]


Interactions

CRIPT has been shown to interact with DLG3.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119878 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024146 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
  6. ^ Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
  7. ^ Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482. S2CID 8145832.
  8. ^ Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
  9. ^ "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
  10. ^ Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24). United States: 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
  • Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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