CPSF7

Protein-coding gene in humans
CPSF7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3N9U

Identifiers
AliasesCPSF7, CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDsMGI: 1917826; HomoloGene: 11731; GeneCards: CPSF7; OMA:CPSF7 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CPSF7
Genomic location for CPSF7
Band11q12.2Start61,402,641 bp[1]
End61,430,031 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for CPSF7
Genomic location for CPSF7
Band19|19 AStart10,502,630 bp[2]
End10,525,017 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • right uterine tube

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • body of uterus

  • left ovary

  • canal of the cervix

  • right ovary

  • ventricular zone

  • gastric mucosa
Top expressed in
  • neural layer of retina

  • mesenteric lymph nodes

  • ventricular zone

  • thymus

  • superior surface of tongue

  • genital tubercle

  • median eminence

  • paraventricular nucleus of hypothalamus

  • maxillary prominence

  • mandibular prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • membrane
  • nucleus
  • nucleoplasm
  • mRNA cleavage factor complex
  • cytoplasm
  • mRNA cleavage and polyadenylation specificity factor complex
Biological process
  • mRNA splicing, via spliceosome
  • termination of RNA polymerase II transcription
  • mRNA processing
  • mRNA 3'-end processing
  • protein tetramerization
  • protein heterotetramerization
  • pre-mRNA cleavage required for polyadenylation
  • mRNA alternative polyadenylation
  • messenger ribonucleoprotein complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79869

269061

Ensembl

ENSG00000149532

ENSMUSG00000034820

UniProt

Q8N684

Q8BTV2

RefSeq (mRNA)

NM_001136040
NM_001142565
NM_024811

NM_001164272
NM_172302
NM_001362450

RefSeq (protein)

NP_001129512
NP_001136037
NP_079087

NP_001157744
NP_758506
NP_001349379

Location (UCSC)Chr 11: 61.4 – 61.43 MbChr 19: 10.5 – 10.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.[5][6]

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. [7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149532 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034820 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
  7. ^ Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Rüegsegger U, Beyer K, Keller W (March 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.


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