CNOT8

Protein-coding gene in the species Homo sapiens
CNOT8
Identifiers
AliasesCNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDsOMIM: 603731; MGI: 1916375; HomoloGene: 48304; GeneCards: CNOT8; OMA:CNOT8 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CNOT8
Genomic location for CNOT8
Band5q33.2Start154,857,553 bp[1]
End154,876,792 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CNOT8
Genomic location for CNOT8
Band11|11 B1.3Start57,994,979 bp[2]
End58,009,420 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • monocyte

  • sperm

  • right lung

  • ganglionic eminence

  • Achilles tendon

  • granulocyte

  • rectum

  • upper lobe of left lung

  • ventricular zone
Top expressed in
  • secondary oocyte

  • neural layer of retina

  • thymus

  • zygote

  • medial ganglionic eminence

  • granulocyte

  • ventricular zone

  • primary oocyte

  • neural tube

  • morula
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • poly(A)-specific ribonuclease activity
  • 3'-5'-exoribonuclease activity
  • DNA-binding transcription factor activity
  • metal ion binding
  • protein binding
  • RNA binding
  • nucleic acid binding
  • nuclease activity
  • exonuclease activity
  • hydrolase activity
Cellular component
  • cytoplasm
  • cytosol
  • CCR4-NOT complex
  • intracellular anatomical structure
  • nucleus
  • P-body
  • CCR4-NOT core complex
Biological process
  • regulation of transcription, DNA-templated
  • nucleic acid phosphodiester bond hydrolysis
  • positive regulation of mRNA catabolic process
  • transcription, DNA-templated
  • gene silencing by miRNA
  • positive regulation of cell population proliferation
  • exonucleolytic catabolism of deadenylated mRNA
  • gene silencing
  • regulation of translation
  • negative regulation of cell population proliferation
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • nuclear-transcribed mRNA poly(A) tail shortening
  • negative regulation of translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9337

69125

Ensembl

ENSG00000155508

ENSMUSG00000020515

UniProt

Q9UFF9

Q9D8X5

RefSeq (mRNA)
NM_001301073
NM_001301074
NM_001301075
NM_001301077
NM_001301080

NM_001301082
NM_001301083
NM_001301086
NM_004779

NM_026949
NM_001356477
NM_001363084
NM_001363085
NM_001363086

RefSeq (protein)
NP_001288002
NP_001288003
NP_001288004
NP_001288006
NP_001288009

NP_001288011
NP_001288012
NP_001288015
NP_004770

NP_081225
NP_001343406
NP_001350013
NP_001350014
NP_001350015

Location (UCSC)Chr 5: 154.86 – 154.88 MbChr 11: 57.99 – 58.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT8 has been shown to interact with BTG2,[8] BTG1,[8][9] CNOT1[6][10] and CNOT3.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155508 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020515 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID 10036195.
  6. ^ a b c Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  7. ^ "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".
  8. ^ a b Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (Pt 2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.
  • Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L (2003). "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. Cell Sci. 116 (Pt 14): 2929–36. doi:10.1242/jcs.00480. PMID 12771185.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C (2007). "Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation". Infect. Immun. 75 (3): 1484–92. doi:10.1128/IAI.01315-06. PMC 1828547. PMID 17178784.


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