CNOT2

Protein-coding gene in humans
CNOT2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4C0D, 4C0F, 5FU6, 5FU7

Identifiers
AliasesCNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDsOMIM: 604909; MGI: 1919318; HomoloGene: 40953; GeneCards: CNOT2; OMA:CNOT2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CNOT2
Genomic location for CNOT2
Band12q15Start70,243,002 bp[1]
End70,354,993 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for CNOT2
Genomic location for CNOT2
Band10|10 D2Start116,321,066 bp[2]
End116,417,416 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • Achilles tendon

  • nipple

  • epithelium of nasopharynx

  • human penis

  • epithelium of colon

  • ganglionic eminence

  • skin of abdomen

  • cerebellar cortex
Top expressed in
  • genital tubercle

  • ciliary body

  • internal carotid artery

  • external carotid artery

  • medullary collecting duct

  • iris

  • tail of embryo

  • primitive streak

  • retinal pigment epithelium

  • cumulus cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • poly(A)-specific ribonuclease activity
  • transcription coregulator activity
  • protein binding
Cellular component
  • cytoplasm
  • membrane
  • CCR4-NOT complex
  • P-body
  • CCR4-NOT core complex
  • nucleus
  • cytosol
  • plasma membrane
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • negative regulation of translation
  • regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • regulation of stem cell population maintenance
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • multicellular organism development
  • positive regulation of cytoplasmic mRNA processing body assembly
  • trophectodermal cell differentiation
  • gene silencing
  • negative regulation of intracellular estrogen receptor signaling pathway
  • regulation of translation
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • RNA phosphodiester bond hydrolysis, exonucleolytic
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4848

72068

Ensembl

ENSG00000111596

ENSMUSG00000020166

UniProt

Q9NZN8

Q8C5L3

RefSeq (mRNA)

NM_001199302
NM_001199303
NM_014515

NM_001037846
NM_001037847
NM_001037848
NM_028082
NM_001359247

NM_001359248
NM_001359249
NM_001359250
NM_001359251
NM_001359252
NM_001359253
NM_001359563

RefSeq (protein)

NP_001186231
NP_001186232
NP_055330

NP_001032935
NP_001032936
NP_001032937
NP_082358
NP_001346176

NP_001346177
NP_001346178
NP_001346179
NP_001346180
NP_001346181
NP_001346182
NP_001346492

Location (UCSC)Chr 12: 70.24 – 70.35 MbChr 10: 116.32 – 116.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene.[5][6] It is a subunit of the CCR4-Not deadenylase complex.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020166 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  6. ^ "Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2".

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zwartjes CG, Jayne S, van den Berg DL, Timmers HT (2004). "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex". J. Biol. Chem. 279 (12): 10848–54. doi:10.1074/jbc.M311747200. PMID 14707134.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shi J, Nelson MA (2005). "The cyclin-dependent kinase 11 interacts with NOT2". Biochem. Biophys. Res. Commun. 334 (4): 1310–6. doi:10.1016/j.bbrc.2005.07.026. PMID 16039607.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Jayne S, Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex". Biochem. J. 398 (3): 461–7. doi:10.1042/BJ20060406. PMC 1559471. PMID 16712523.


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