Protein-coding gene in the species Homo sapiens
CDC42EP3 |
---|
|
Identifiers |
---|
Aliases | CDC42EP3, BORG2, CEP3, UB1, CDC42 effector protein 3 |
---|
External IDs | OMIM: 606133; MGI: 2384718; HomoloGene: 4708; GeneCards: CDC42EP3; OMA:CDC42EP3 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 2 (human)[1] |
---|
| Band | 2p22.2 | Start | 37,641,882 bp[1] |
---|
End | 37,738,468 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 17 (mouse)[2] |
---|
| Band | 17|17 E3 | Start | 79,641,156 bp[2] |
---|
End | 79,662,520 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - tibia
- monocyte
- seminal vesicula
- myocardium of left ventricle
- glomerulus
- metanephric glomerulus
- saphenous vein
- right ventricle
- tail of epididymis
- myometrium
|
| Top expressed in | - spermatocyte
- condyle
- tibiofemoral joint
- tunica media of zone of aorta
- granulocyte
- vas deferens
- urinary bladder
- seminiferous tubule
- calvaria
- ascending aorta
|
| More reference expression data |
|
---|
BioGPS |
| More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - GTPase activator activity
- cytoskeletal regulatory protein binding
- protein binding
| Cellular component | - cytoplasm
- cytosol
- cytoskeleton
- membrane
- endomembrane system
- actin cytoskeleton
- plasma membrane
| Biological process | - positive regulation of pseudopodium assembly
- positive regulation of actin filament polymerization
- Rho protein signal transduction
- signal transduction
- regulation of cell shape
- positive regulation of GTPase activity
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | NM_001270436 NM_001270437 NM_001270438 NM_006449 NM_001371569
|
---|
NM_001371570 |
| |
---|
RefSeq (protein) | NP_001257365 NP_001257366 NP_001257367 NP_006440 NP_001358498
|
---|
NP_001358499 |
| |
---|
Location (UCSC) | Chr 2: 37.64 – 37.74 Mb | Chr 17: 79.64 – 79.66 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.[5][6][7]
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.[7]
Interactions
CDC42EP3 has been shown to interact with CDC42[5][8] and RHOQ.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163171 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036533 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
- ^ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
- ^ a b "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
- ^ a b Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628. PMID 10490598.
External links
Further reading
- Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Joberty G, Perlungher RR, Sheffield PJ, et al. (2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nat. Cell Biol. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID 11584266. S2CID 58805.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.