CDC23

Protein-coding gene in the species Homo sapiens

CDC23

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4UI9, 5A31, 5G05, 5G04

Identifiers

Aliases

CDC23, ANAPC8, APC8, CUT23, cell division cycle 23

External IDs

OMIM: 603462; MGI: 1098815; HomoloGene: 3426; GeneCards: CDC23; OMA:CDC23 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q31.2	Start	138,187,650 bp^[1]
Band	5q31.2	End	138,213,343 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18 B1\|18 18.69 cM	Start	34,764,004 bp^[2]
Band	18 B1\|18 18.69 cM	End	34,784,788 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

ventricular zone

tibia

endothelial cell

rectum

cerebellar hemisphere

right hemisphere of cerebellum

ovary

islet of Langerhans

left ovary

Top expressed in

genital tubercle

tail of embryo

ventricular zone

mandibular prominence

medullary collecting duct

superior cervical ganglion

maxillary prominence

abdominal wall

ganglionic eminence

renal corpuscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ubiquitin-protein transferase activity protein binding
Cellular component	nucleoplasm cytosol intracellular anatomical structure anaphase-promoting complex
Biological process	ubiquitin-dependent protein catabolic process regulation of exit from mitosis regulation of mitotic metaphase/anaphase transition cell cycle cell division protein K11-linked ubiquitination metaphase anaphase-promoting complex-dependent catabolic process protein ubiquitination mitotic metaphase plate congression mitotic cell cycle regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8697


52563

Ensembl


ENSG00000094880


ENSMUSG00000024370

UniProt


Q9UJX2


Q8BGZ4

RefSeq (mRNA)


NM_004661


NM_178347

RefSeq (protein)


NP_004652


NP_848124

Location (UCSC)

Chr 5: 138.19 – 138.21 Mb

Chr 18: 34.76 – 34.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[5]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.^[5]

Interactions

CDC23 has been shown to interact with CDC27.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000094880 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024370 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
^ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

External links

Human CDC23 genome location and CDC23 gene details page in the UCSC Genome Browser.

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Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM (Dec 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
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