Aquaporin-6

Protein-coding gene in the species Homo sapiens

AQP6

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1S6E

Identifiers

Aliases

AQP6, AQP2L, KID, aquaporin 6

External IDs

OMIM: 601383; MGI: 1341204; HomoloGene: 20399; GeneCards: AQP6; OMA:AQP6 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.12	Start	49,967,194 bp^[1]
Band	12q13.12	End	49,977,139 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 F1\|15 56.13 cM	Start	99,499,281 bp^[2]
Band	15 F1\|15 56.13 cM	End	99,503,358 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

orbitofrontal cortex

kidney tubule

endothelial cell

inferior ganglion of vagus nerve

human kidney

thalamus

subthalamic nucleus

ventral tegmental area

gonad

Top expressed in

cerebellar vermis

lumbar subsegment of spinal cord

lobe of cerebellum

habenula

human kidney

inner renal medulla

right kidney

Transitional epithelium of renal pelvis

embryo

dorsal tegmental nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nitrate transmembrane transporter activity water channel activity channel activity
Cellular component	integral component of membrane cytoplasmic vesicle integral component of plasma membrane apical plasma membrane membrane cytoplasmic vesicle membrane plasma membrane
Biological process	nitrate transport excretion odontogenesis ion transmembrane transport transmembrane transport water transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


363


11831

Ensembl


ENSG00000086159


ENSMUSG00000043144

UniProt


Q13520


Q8C4A0

RefSeq (mRNA)


NM_053286 NM_001652


NM_175087

RefSeq (protein)


NP_001643


NP_780296

Location (UCSC)

Chr 12: 49.97 – 49.98 Mb

Chr 15: 99.5 – 99.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene.^[5]

The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086159 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043144 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10.

External links

Human AQP6 genome location and AQP6 gene details page in the UCSC Genome Browser.

Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (Oct 2002). "Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63". The Journal of Biological Chemistry. 277 (42): 39873–9. doi:10.1074/jbc.M207008200. PMID 12177001.
Ma T, Yang B, Umenishi F, Verkman AS (Aug 1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
Ishiyama G, Lopez IA, Beltran-Parrazal L, Ishiyama A (Jun 2010). "Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma". Cell and Tissue Research. 340 (3): 407–19. doi:10.1007/s00441-010-0975-7. PMC 2882038. PMID 20461409.
Wang W, Hart PS, Piesco NP, Lu X, Gorry MC, Hart TC (Mar 2003). "Aquaporin expression in developing human teeth and selected orofacial tissues". Calcified Tissue International. 72 (3): 222–7. doi:10.1007/s00223-002-1014-9. PMID 12522663. S2CID 24539238.
Yusenko MV, Zubakov D, Kovacs G (2009). "Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours". International Journal of Biological Sciences. 5 (6): 517–27. doi:10.7150/ijbs.5.517. PMC 2726578. PMID 19680475.
Ma T, Yang B, Kuo WL, Verkman AS (Aug 1996). "cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13". Genomics. 35 (3): 543–50. doi:10.1006/geno.1996.0396. PMID 8812490.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin